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PIERPAOLI
Melatonin Zinc-Selenium 60 tablets

Rating 4,75/5 (Number of votes: 8) vote
Customer Reviews: 2

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€ 11,85 € 15,80

 


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Pierpaoli Melatonina Zinco-Selenio 60 tablets. Formulation is based on a large number of basic scientific observations obtained and confirmed during 35 years of research and clinical studies.

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Pierpaoli - Melatonin Zinc-Selenium - IAFSTORE.COM

PIERPAOLI MELATONINA ZINCO-SELENIO

Dietary supplement


Formulation is based on a large number of basic scientific observations obtained and confirmed during 35 years of research and clinical studies.

It is the only Melatonin product produced according to the specific formula and under the scientific control of the melatonin expert Dr. Walter Pierpaoli.
This formulation is based on a large number of basic scientific observations obtained and confirmed during 35 years of research and clinical studies, which have been documented and published in renowned scientific journals by Dr. Pierpaoli and co-workers. Melatonin Zinc-Selenium has been developed by Dr. Pierpaoli using a special selection and combination of ACTIVE MOLECULES and EXCIPIENTS in order to reproduce the body’s typical physiologic night peak of Melatonin, which is produced by the pineal gland during young age.
The nocturnal Melatonin release maintains the biological circadian rhythm which controls the hormones and immunity.

Melatonin Zn-Se is suitable to regulate, resynchronize and improve the fundamental hormonal, metabolic and immunobiological functions, which are normally deranged in the course of ageing.
Melatonin Zn-Se contains synergistic components to obtain more rapid metabolic and immunological effects and to compensate the loss of fundamental minerals, due to bad diet or ageing.

In summary melatonin plays the master role for reactivation and restoration of its natural night peak to juvenile levels.

This resulting in normalization of all measurable immunological and endocrine functions in the course of ageing. The positive age-postponing, metabolic and immunological effects of Melatonin Zn-Se can be easily measured by anybody by means of a normal periodic check-up.

These restoring metabolic changes will become progressively more visible and remarkable during a continous treatment with Melatonin Zn-Se.

Indeed clinical trials using Dr.Pierpaoli’s melatonin have supported its efficacy for:

  • Improved fertility
  • Enhanced immunity
  • Easier travel by removal of jet-lag
  • Easier adaptability to shift/ night work
  • Alleviation of menopause symptoms
  • Advantages to those suffering from senility and dementias
  • Improved/ deeper sleep patterns
  • Normalisation of circadian rhythms
  • Improvements to Syndrome X
  • Increased well being


Formula: Active Molecules

Melatonin: Melatonin produced by the pineal gland seems to be responsible for the melatonin night peak, while melatonin produced by the gut and the retina does not seem to affect the nocturnal levels.
The night peak of melatonin initiates a sequence of positive effects with a cascade of events which maintain the body systems synchronized with the physiological cyclicity of all hormones and cells.
Circadian night melatonin produces a resynchronization of the entire hormonal system and improves metabolic and hormonal functions, including blood pressure, cholesterol levels, thyroid, gonad and adrenal functions.
Melatonin will counteract the negative side-effects of corticosteroids and stressful agents, thus protecting the immune system.
Melatonin does not induce sleep but facilitates its onset and produces a sleep pattern which is typical in children.
Thus, it greatly improves the quality of sleep and its restoring physical and psychological effects, with a clear improvement of morning mood and body muscle strength.
Melatonin is found in nature in all cells, plants, animals, tissues and all living organisms.
Its nocturnal release is essential for the maintenance of immunity and the "surveillance" against the onset of tumors.
Therefore, melatonin is a fundamental element for prevention of age-related diseases, including cancer, autoimmune and cardiovascular diseases.
Melatonin cannot be considered a classical "hormone" because it does not possess any of the qualities of the classical hormones such as growth hormone, cortisone, estrogens, thyroid hormones, etc. Rather it modulates and controls the synthesis and secretion of all hormones within a circadian and seasonal periodicity.
It is this correction of the circadian clock that enables the restoration and correction of the derangements to enable maintenance of original juvenile conditions.
Zinc: Many studies have observed that zinc can correct age-dependent immuno-depression and several other hormonal and metabolic alterations typical of ageing.
Zinc is an essential component of more than 200 enzymes and one of the most important trace elements in the body. Studies of Dr. Pierpaoli and co-workers have shown that melatonin alone produces an increase of zinc levels in the blood of older animals. This important observation of the powerful anti-aging and immuno-enhancing activity of the combination of zinc and melatonin has resulted in the development of Melatonin Zn-Se.
Selenium: Selenium is a fundamental trace element of the body and possesses powerful anti-cancer effects. Modern agriculture and alimentary habits have dramatically decreased the quantity of selenium from the diet. Selenium is essential for the enzymatic reaction responsible for the synthesis of glutathione, a powerful physiological molecule which constantly protects the body from oxidative damage.
A lack of selenium will thus result in a loss of the detoxification capacity of the body, immunodepression and onset of degenerative diseases and cancer.

This is the reason why Melatonin Zn-Se combines these 3 fundamental anti-ageing molecules of melatonin, zinc and selenium.
Whilst melatonin plays the master role for reactivation and restoration of the natural melatonin night peak to juvenile levels, (thus resulting in a normalization of all measurable immunological and endocrine functions), the positive age-postponing, metabolic and immunological effects of Melatonin Zn-Se becomes progressively more visible and remarkable.
Over time, the "program of ageing" can be slowed down with regular nocturnal use of Melatonin Zn-Se.
?Melatonin Zn-Se constitutes an outstanding melatonin preparation now available on the market since it has been prepared based on 35 years of research, scientific studies and clinical observations of Dr. Pierpaoli and his co-workers.
The basic experimental findings, resulted in the discovery of the existence of a programmed “Ageing Clock” in the pineal gland complex of the brain -governed by naturally secreted pineal gland melatonin with its quantities declining with age- has been relentlessly continued in order to further improve the anti-aging activity of circadian, night melatonin.

Melatonin Zn-Se Dr.Pierpaoli is more than “just” melatonin

Dr. Pierpaoli has carefully designed his product to give it a number of benefits over “plain regular” melatonin.
For example, during recent studies and longterm experiments with old rodents, it has been observed that zinc can completely correct age-dependent immunodepression and several other hormonal and metabolic alterations typical of ageing.
It has been found that the low zinc levels in ageing animals can be restored to normal values with nocturnal administration of melatonin or transplantation of the pineal gland from young into older animals.
The natural night peak
A very special feature of Dr. Pierpaoli’s product is its ability to release melatonin in the same way as the natural release from the brain’s pineal gland takes place.
Scientific observations emerging and matured during 35 years of research and clinical studies carried out by Prof. Pierpaoli, led to a specific Melatonin formulation, capable of reproducing in the body the physiologic night peak of Melatonin, as produced by the pineal gland between 1 and 3 am, a night peak which is typical of a young age!

It is during childhood that the production of Melatonin reaches its maximal peak of about 125 picograms (125 billionths of a gram) per day.
After a sharp decline at puberty, the night production of Melatonin begins to decline slowly.
At around 45 years of age there is a further breakdown and at around 80 years of age, the level of Melatonin in the body of an otherwise healthy person is about half that of a young man of 20 years.
Melatonin Zn-Se helps to reverse this trend and maintains a constant nocturnal Melatonin peak which is typical of youth.
By this way the juvenile Melatonin night peak thus produced maintains the biological rhythms which control your hormones and your immunity and, consequently, the circadian synchronization( the physiologic cyclicity) of the entire hormone ( neuroendocrine) system, that tightly regulates the natural metabolic and immunological functions.

Prof. Pierpaoli and colleagues have discovered, through a great number of in vivo experiments in several decades, that the re-synchronization of the hormones (neuroendocrine) cyclicity directed by the Pineal Gland and its maintenance and protection by a proper nocturnal administration of Melatonin, starting at a relatively young age (30 to 35 years old) helps to maintain the body’s youthful conditions.
Using an original formulation, Pierpaoli has achieved the realization of Melatonin Zn-Se, which mimics Nature, by producing a night peak release of Melatonin in the same way as during normal youth.
In this way, the assumption of Melatonin Zn-Se helps the Pineal Gland to regenerate and to keep youthful conditions, with the result of newly synchronizing and regulating all immunologic, metabolic and endocrine functions, which are normally deranged in the course of aging!

Normal and especially sublingual and time-released versions of melatonin are unable to do this, only Dr. Pierpaoli’s Melatonin Zn Se has been designed, tried and tested for this purpose.


References

  • 1. JELLIN JM ET AL., EDS. Pharmacist’s letter/prescriber’s letter natural medici- nes comprehensive database.
  • 2. HARTTER S ET AL. Increased bioavailability of oral melatonin after fluvoxami- ne coadministration. Clin Pharmacol Ther. 2000; 67:1-6.
  • 3. VON BAHR C ET AL. Fluvoxamine but not citalopram increases serum me- latonin in healthy subjects -- an indication that cytochrome P450 CYP1A2 and CYP2C19 hydroxylate melatonin. Eur J Clin Pharmacol. 2000; 56:123-7.
  • 4. LUSARDI P ET AL. Cardiovascular effects of melatonin in hypertensive pa- tients well controlled by nifedipine: a 24-hour study. Br J Clin Pharmacol. 2000; 49:423-7.
  • 5. PIERPAOLI, W. AND REGELSON W. WITH CAROL COLMAN, “The Mela- tonin Miracle”, Simon & Schuster, New York, 1995.
  • 6. PIERPAOLI, W. The pineal gland: a circadian or a seasonal aging clock? Aging 3: 99-101, 1991.
  • 7. PIERPAOLI, W. DALL’ARA, A, PEDRINIS, E. AND REGELSON, W. The pineal control of aging. The effects of melatonin and pineal grafting on the survival of older mice.
  • 8. Second Stromboli Conference on Aging and Cancer, June 1990. Ann. N.Y. Acad. Sci. 621: 291-313, 1991.
  • 9. PIERPAOLI, W., AND LESNIKOV, V.A. The pineal aging clock. Evidence, mo- dels, mechanisms, interventions. The Aging Clock. Third Stromboli Conference on Agingand Cancer, June 1993. Ann. N.Y. Acad. Sci. 719: 461-473, 1994.
  • 10. PIERPAOLI, W. AND REGELSON, W. Pineal control of aging: effect of mela- tonin and pineal grafting on aging mice. Proc. Natl. Acad. Sci. USA, 94: 787-791, 1994.
  • 11. MOCCHEGIANI, E., BULIAN, D., SANTARELLI, L., TIBALDI, A., MUZZIOLI, M., PIERPAOLI, W. AND FABRIS, N. The immuno-reconstituting effect of melato- nin or pineal grafting and its relation to zinc pool in aging mice. J. Neuroimmunol. 53: 189-201, 1994.
  • Melatonina Zinco-Selenio Dr.Pierpaoli
  • 12. MOCCHEGIANI, E., BULIAN, D., SANTARELLI, L., TIBALDI, A., MUZZIOLI, M., LESNIKOV, V., PIERPAOLI, W. AND FABRIS, N. The zinc pool is involved in the immunoreconstituting effect of melatonin in pinealectomized mice. J. Phar- mac. & Exp. Therap. 277: 1200-1208, 1996.
  • 13. MOCCHEGIANI, E., BULIAN, D., SANTARELLI, L., TIBALDI, A., PIERPAOLI, W. AND FABRIS, N. The zinc-melatonin interrelationship. A working hypothesis. The Aging Clock.
  • 14. Third Stromboli Conference on Aging and Cancer, June 1993. Ann. N.Y. Acad. Sci. 719: 298-307. 1994.
  • 15. FABRIS, N. Neuroendocrine-immune aging: an integrative view on the role of zinc. The Aging Clock. Third Stromboli Conference on Aging and Cancer, June 1993.
  • 16. ANN. N.Y. Acad. Sci. 719: 353-368, 1994. 17. MEISTER, A. AND ANDERSON, M.E. Glutathione. Ann. Rev. Biochem. 52:
  • 711-760, 1983. 18. PIERPAOLI, W. AND LESNIKOV, V.A. Theoretical considerations on the na-
  • ture of the pineal “aging clock”. Gerontology 43: 20-25, 1997.
  • 19. BELLIPANNI, G., BIANCHI. P, PIERPAOLI, W., BULIAN, D. AND ILYIA, E.
  • Effects of melatonin in perimenopausal and menopausal women. A randomized and placebo controlled study. Exp. Gerontol. 36, 297-310, 2001.


RECOMMENDATION: take a tablet Melatonin Zinc-Selenium Pierpaoli in the evening half an hour before bedtime.


NET WEIGHT: 12 grams

STORAGE: Keep in a cool dry place.

Mean analysis
Per 100g
Per dose (1 tablet)
     
Melatonin 0,5g 1mg
Zinc 4,35g 8,7mg (87%*)
Selenium 0,025g 50mcg (90%*)
     
* Percent Daily Values are based on a 2,000 calorie diet

Warnings: Consult a physician prior to use if you have any medical condition. This product is not intended to diagnose, treat, cure, or prevent any disease. For use as a dietary supplement only. This product is not intended to replace a varied and balanced nutrition. Keep out of reach of children. Store in a cool, dry place.
Salva

Customer Reviews (2)

I don't want to by something…
by USER ID 477070 on 10/01/2018
I don't want to by something alse a the moment - so you can't send me my order?
Ottimo prodotto. Effetto…
by USER ID 340958 on 29/07/2017
Ottimo prodotto. Effetto melatonins efficace. I due elementi in più sono una scelta intelligente