YAMAMOTO NUTRITION
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 YAMAMOTO® NUTRITION
Regexil®
Yamamoto® Nutrition Regexil® is a food supplement based on melatonin with valerian, passion flower and chamomile, with GABA, theanine and plant extracts, suitable for adults. Diet and training are the key factors of the successful athlete, but certainly sleep is another crucial factor that often is an objective limit for the athlete, especially when under a particular phase of psychophysical stress of a preparation, where many athletes encounter difficulties. getting adequate sleep or rest. During the phases of sleep, the athlete carries out the processes of muscle reconstruction, and the immune system as well as the nervous system is conditioned in a fundamental way, bearing in mind that if you sleep little or with poor sleep quality, insulin sensitivity will also be it penalized, to the detriment of the effectiveness of the diet. Per the body builder, sleep is almost essential because it affects practically all factors, including endocrine and pain sensitivity. The Yamamoto Nutrition Flex Series line could not fail to present a product that could also help this essential aspect for the optimal recovery of an athlete, and thus REGEXIL was born, one of the best and efficient products to promote falling asleep and quality of sleep on the market. based on a highly synergistic blend of valerian extract, passionflower extract, chamomile, griffonia, theanine, GABA, and Melatonin. The dry extract of Valerian contains compounds (valepotriates, lignans, alkaloids and an essential oil that contains valerenic acids) with a sedative, calming, spasmolytic and muscle relaxant action that reduces anxiety and counteracts stress, gently promoting sleep induction . These compounds act on the GABAaergic control mainly through the inhibition of the degradation and presynaptic reuptake of GABA and the promotion of its synthesis. Therefore, since GABA is an inhibitory neurotransmitter, these substances that increase the activity of GABAergic synapses depress the activity of the central nervous system, with the desired relaxing and anxiolytic effect. Passiflora is one of the most used herbal and phytotherapeutic remedies, as a natural remedy to combat anxiety and insomnia, thanks to its calming and sedative effect due to its flavonoids and the many other compounds it contains (alkaloids, phytosterols, acids phenols, coumarins, heterosides, cyanogenic), but also to induce muscle relaxation thanks to its spasmodic and relaxing action on the nervous system in a synergistic way with Chamomile which exerts a beneficial action on the nervous system, on the digestive and immune systems with anti-inflammatory properties and carminative. Griffonia has long been used as a support to mood in states of anxiety and high tension and in insomnia, as it naturally raises serotonin levels and regulates the sleep-wake cycle ("circadian rhythm"), as specifically, its seeds contain 5-hydroxy-tryptophan (5-HTP). Theanine is an amino acid contained in green tea, which has the ability to stimulate the alpha waves of the brain, which promote deep relaxation, and is involved in the formation of GABA (gammaaminobutyric acid), which in turn amplifies its action. inhibitory and affects two other neurotransmitters, dopamine and serotonin, which will further promote the greater sense of calm. The main function of γ-aminobutyric acid "GABA", as an inhibitory neurotransmitter, is to "slow down" brain activity and is involved in aspects such as: vision, sleep, muscle tone and motor control. Not only do we talk about the level of the nervous system, but it is also found in the intestines, stomach, bladder, lungs, liver, skin, spleen, muscles, kidneys, pancreas and reproductive organs. One of the most important functions of γ-aminobutyric acid is its ability to reduce stress and anxiety. When its levels are low, the chances of feeling anxious, tired and very sensitive to stimuli increase. GABA is another valuable element contained in REGEXIL, In a powerful blend to counteract sleep problems, the now well-known melatonin could not be missing, a precious element for our body, to rebalance the circadian rhythm of sleep. Not only "regulator", but also "inducer" effective for those who suffer from phase delay syndrome (DSP) or initial insomnia, those who struggle to fall asleep, where melatonin would favor the shortening of the times of falling asleep. This without modifying effects on sleep architecture, not altering the balance between the alternation of the times of the N-REM and REM phases. The effectiveness of REGEXIL is further emphasized thanks to the fact that the elements it contains are inserted in the context of a latest generation triple layer tablet, which features a differentiated release technology to optimize the gradual and targeted release of each single element over time. SCIENTIFIC REFERENCES:
Halson SL. Sleep in elite athletes and nutritional interventions to enhance sleep. Sports Med. 2014 May;44 Suppl 1(Suppl 1):S13-23. doi: 10.1007/s40279-014-0147-0. PMID: 24791913; PMCID: PMC4008810 Bent S, Padula A, Moore D, Patterson M, Mehling W. Valerian for sleep: a systematic review and meta-analysis. Am J Med. 2006 Dec;119(12):1005-12. doi: 10.1016/j.amjmed.2006.02.026. PMID: 17145239; PMCID: PMC4394901. Salter S, Brownie S. Treating primary insomnia - the efficacy of valerian and hops. Aust Fam Physician. 2010 Jun;39(6):433-7. PMID: 20628685. Guerrero FA, Medina GM. Effect of a medicinal plant (Passiflora incarnata L) on sleep. Sleep Sci. 2017 Jul-Sep;10(3):96-100. doi: 10.5935/1984-0063.20170018. PMID: 29410738; PMCID: PMC5699852. da Fonseca LR, Rodrigues RA, Ramos AS, da Cruz JD, Ferreira JLP, Silva JRA, Amaral ACF. Herbal Medicinal Products from Passiflora for Anxiety: An Unexploited Potential. ScientificWorldJournal. 2020 Jul 20;2020:6598434. doi: 10.1155/2020/6598434. PMID: 32765195; PMCID: PMC7387951. Mao JJ, Xie SX, Keefe JR, Soeller I, Li QS, Amsterdam JD. Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial. Phytomedicine. 2016 Dec 15;23(14):1735-1742. doi: 10.1016/j.phymed.2016.10.012. Epub 2016 Oct 24. PMID: 27912875; PMCID: PMC5646235. Shinomiya K, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C. Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats. Biol Pharm Bull. 2005 May;28(5):808-10. doi: 10.1248/bpb.28.808. PMID: 15863883. Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008;17 Suppl 1:167-8. PMID: 18296328. Kim S, Jo K, Hong KB, Han SH, Suh HJ. GABA and l-theanine mixture decreases sleep latency and improves NREM sleep. Pharm Biol. 2019 Dec;57(1):65-73. doi: 10.1080/13880209.2018.1557698. PMID: 30707852; PMCID: PMC6366437. Wisden W, Yu X, Franks NP. GABA Receptors and the Pharmacology of Sleep. Handb Exp Pharmacol. 2019;253:279-304. doi: 10.1007/164_2017_56. PMID: 28993837. Yamatsu A, Yamashita Y, Pandharipande T, Maru I, Kim M. Effect of oral γ-aminobutyric acid (GABA) administration on sleep and its absorption in humans. Food Sci Biotechnol. 2016 Apr 30;25(2):547-551. doi: 10.1007/s10068-016-0076-9. PMID: 30263304; PMCID: PMC6049207. Hepsomali P, Groeger JA, Nishihira J, Scholey A. Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review. Front Neurosci. 2020 Sep 17;14:923. doi: 10.3389/fnins.2020.00923. PMID: 33041752; PMCID: PMC7527439. Tordjman S, Chokron S, Delorme R, Charrier A, Bellissant E, Jaafari N, Fougerou C. Melatonin: Pharmacology, Functions and Therapeutic Benefits. Curr Neuropharmacol. 2017 Apr;15(3):434-443. doi: 10.2174/1570159X14666161228122115. PMID: 28503116; PMCID: PMC5405617. Zisapel N. New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Br J Pharmacol. 2018 Aug;175(16):3190-3199. doi: 10.1111/bph.14116. Epub 2018 Jan 15. PMID: 29318587; PMCID: PMC6057895. Ferracioli-Oda E, Qawasmi A, Bloch MH. Meta-analysis: melatonin for the treatment of primary sleep disorders. PLoS One. 2013 May 17;8(5):e63773. doi: 10.1371/journal.pone.0063773. PMID: 23691095; PMCID: PMC3656905. Directions: take 1 tablet a day with water close to bedtime. Net content: 39 g
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30 tablets |
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Nutrition facts |
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Serving size: 1 tablet |
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Servings per container: 30 |
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| Per daily dose (1 tablet) |
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| Valerian extract of which valerenic acids |
150 mg 0,6 mg |
| Passionflower extract of which vitexin |
150 mg 0,75 mg |
| Chamomile extract of which apigenin |
100 mg 0,3 mg |
| Griffonia extract of which 5-HTP |
102 mg 100 mg |
| Theanine | 100 mg |
| Gamma-aminobutyric acid (GABA) | 100 mg |
| Melatonine | 1 mg |
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Ingredients: bulking agents: cellulose, dicalcium phosphate, hydroxy-propyl-methylcellulose, cross-linked sodium carboxymethylcellulose; valerian dry extract (Valeriana officinalis L.) root 0.4% valerenic acids, passionflower dry extract (Passiflora incarnata L.) aerial parts with flowers 0.5% vitexin, Griffonia dry extract [Griffonia simplicifolia (DC.) Baill .] seeds 98% 5-hydroxy-L-tryptophan (5-HTP), chamomile dry extract (Matricaria chamomilla L.) flowers 0.3% apigenin, L-theanine, gamma-aminobutyric acid (GABA), anti-caking agents: silicon dioxide, magnesium salts of fatty acids; colour: E 172; melatonin. |
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