YAMAMOTO RESEARCH
Capelli, pelle e unghie LIQUIDO 20 x 25ml

Yamamoto® Research Capelli, pelle e unghie LIQUIDO is a new-generation food supplement designed to nourish and support the health and trophism of hair, skin and nails.

These elements are extremely susceptible to the passage of time, and as they age, the elements that provide greater tone and firmness are lost, making them more fragile, thinner, and less "healthy". It is not only ageing that affects the health of the skin, hair and nails. It is enough to think of a period of strong psychophysical stress, an unbalanced diet, or the presence of specific illnesses which then often affect the state of well-being of the hair, skin and nails.

The formulation of Capelli, pelle e unghie LIQUIDO is characterised by a blend of antioxidant, trophic and nourishing elements such as: ExceptionHYAL® Star hyaluronic acid, Pycnogenol®, Coenzyme Q10, Vitamin C, Zinc, Beta-carotene, Watts'up®, Copper and Biotin.

ExceptionHYAL® Star Hyaluronic Acid is a biotechnological ingredient belonging to the new generation of hyaluronic acids, based on a specific spectrum of molecular weights, which supports the physiological health of the skin by acting on the release of its metabolites and strongly promotes the endogenous synthesis of HA within the skin. Its action from within makes the skin more hydrated and allows for a more efficient barrier effect, improving the appearance and tone of the skin, increasing its elasticity, smoothness and reducing wrinkles. The full spectrum molecular weight makes ExceptionHYAL® Star the best compromise in terms of enzymatic stability, anti-inflammatory activity and antioxidant capacity.

Pycnogenol® is an active ingredient extracted from French maritime pine bark. A large number of studies in its favour have demonstrated not only its effectiveness as a powerful antioxidant, anti-inflammatory, antithrombotic and anti-allergic, but also as an interesting ally in skin health, primarily as a powerful antioxidant against the negative effects of excess oxidative stress. The benefits for the skin also extend to its ability to bind with collagen and elastin, protecting the skin from the negative effects of UV rays, helping to strengthen its elasticity and tone, making it younger and brighter. Pycnogenol has been shown to be effective in reducing the intensity and extent of pigmentation of brown or grey skin spots, caused by the hyperactivity of melanocytes, which are frequent in the ageing process.

The presence of Coenzyme Q10 significantly boosts its antioxidant effects, together with Vitamin C (which further supports collagen production), Beta-carotene and Zinc, a deficiency of which leads to hair loss, dry and brittle hair and nails which break more easily. This valuable mineral is needed to maintain a healthier skin, in the treatment of acne or psoriasis and dermatitis, by promoting skin tissue renewal and wound healing.
Watts'up® is a patent based on Hesperidin, a compound derived from the membranes and peels of citrus fruits, which provide a wealth of skin benefits, including anti-inflammatory, antioxidant and skin-lightening properties, restoring and repairing the protective barrier.
Biotin (or Vitamin B7 or H) is essential for maintaining healthy skin, nails and hair. It plays a very important role in the growth and strengthening of hair and nails through its involvement in keratin synthesis.

Keratin is the main protein in hair and nails, giving them tone, structure and strength, and it is no coincidence that signs of its deficiency also include rashes, loss and/or fragility of nails and hair.
Copper is a trace element that helps slow down ageing and prevent brittleness of the hair and nails, possessing the property of stimulating elastin production, collagen formation, stimulating melanin production and promoting the keratinisation processes of the hair but also of the skin, to ensure greater trophism and health of the connective tissue in general.

SCIENTIFIC REFERENCES

Cicero AFG, Girolimetto N, Bentivenga C, Grandi E, Fogacci F, Borghi C. Short-Term Effect of a New Oral Sodium Hyaluronate Formulation on Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial. Diseases. 2020 Jul 8;8(3):26. doi: 10.3390/diseases8030026. PMID: 32650511; PMCID: PMC7564147.

Bukhari SNA, Roswandi NL, Waqas M, Habib H, Hussain F, Khan S, Sohail M, Ramli NA, Thu HE, Hussain Z. Hyaluronic acid, a promising skin rejuvenating biomedicine: A review of recent updates and pre-clinical and clinical investigations on cosmetic and nutricosmetic effects. Int J Biol Macromol. 2018 Dec;120(Pt B):1682-1695. doi: 10.1016/j.ijbiomac.2018.09.188. Epub 2018 Oct 1. PMID: 30287361.

Oe M, Mitsugi K, Odanaka W, Yoshida H, Matsuoka R, Seino S, Kanemitsu T, Masuda Y. Dietary hyaluronic acid migrates into the skin of rats. ScientificWorldJournal. 2014;2014:378024. doi: 10.1155/2014/378024. Epub 2014 Oct 14. PMID: 25383371; PMCID: PMC4213400.
Göllner I, Voss W, von Hehn U, Kammerer S. Ingestion of an Oral Hyaluronan Solution Improves Skin Hydration, Wrinkle Reduction, Elasticity, and Skin Roughness: Results of a Clinical Study. J Evid Based Complementary Altern Med. 2017 Oct;22(4):816-823. doi: 10.1177/2156587217743640. Epub 2017 Dec 4. PMID: 29228816; PMCID: PMC5871318.

Scarano A, Sbarbati A, Amore R, Iorio EL, Ferraro G, Marchetti M, Amuso D. The role of hyaluronic acid and amino acid against the aging of the human skin: A clinical and histological study. J Cosmet Dermatol. 2021 Jul;20(7):2296-2304. doi: 10.1111/jocd.13811. Epub 2020 Nov 9. PMID: 33090687.

Grether-Beck S, Marini A, Jaenicke T, Krutmann J. French Maritime Pine Bark Extract (Pycnogenol®) Effects on Human Skin: Clinical and Molecular Evidence. Skin Pharmacol Physiol. 2016;29(1):13-7. doi: 10.1159/000441039. Epub 2015 Oct 23. PMID: 26492562.

Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, Brenden H, Schönlau F, Krutmann J. Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women. Skin Pharmacol Physiol. 2012;25(2):86-92. doi: 10.1159/000335261. Epub 2012 Jan 21. PMID: 22270036.

Zhao H, Wu J, Wang N, Grether-Beck S, Krutmann J, Wei L. Oral Pycnogenol® Intake Benefits the Skin in Urban Chinese Outdoor Workers: A Randomized, Placebo-Controlled, Double-Blind, and Crossover Intervention Study. Skin Pharmacol Physiol. 2021;34(3):135-145. doi: 10.1159/000514323. Epub 2021 Mar 31. PMID: 33789311.

Pycnogenol® inhibits release of enzymes involved in breaking-down collagen and elastin in inflamed skin in humans.
Grimm T, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Durackova Z, Högger P
Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol®). J Inflamm 3: 1-6, 2006

Evidence of percutaneous absorption of Pycnogenol® in human skin.

Sarikaki V, Rallis M, Tanojo H, Panteri I, Dotsikas Y, Loukas YL, Papaioannou G, Demetzos C, Weber S, Moini H, Maibach HI, Packer L
In vitro percutaneous absorption of pine bark extract (Pycnogenol®) in human skin.
J Toxicol Cutaneous Ocul Toxicol 23: 149-158, 2004

The collagen and elastin destroying enzymes are potently inhibited by Pycnogenol® as well as its metabolites prevailing in humans after oral consumption.
Grimm T, Schäfer A, Högger P
Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (Pycnogenol®). J Free Radic Biol Med 36: 811-822, 2004

Pycnogenol® dose-dependently protects the skin from ultraviolet-radiation-induced oxidative stress injury (lipid peroxidation and cytotoxicity). Guochang Z Ultraviolet radiation-induced oxidative stress in cultured human skin fibroblasts and antioxidant protection.

Bio Res Rep Univ Jyväskylä 33: 1-86, 1993

Review summarizing the beneficial effects of Pycnogenol® for skin care. Schönlau F The cosmeceutical Pycnogenol®.
J Appl Cosmetol 20: 241-246, 2002

 Pycnogenol® counteracts skin hyper-pigmentation in women. Ni Z, Mu Y, Gulati O Treatment of melasma with Pycnogenol®. Phytother Res 16: 567-571, 2002

Zhang, Ru-zhi, et al. "Effect of hesperidin on B16 and HaCaT cell lines irradiated by Narrowband-UVB light." JOURNAL OF CLINICAL DERMATOLOGY-NANJING- 37.3 (2008): 146.

Galati, E. M., et al. "Biological effects of hesperidin, a citrus flavonoid.(Note I): antiinflammatory and analgesic activity." Farmaco (Societa chimica italiana: 1989) 40.11 (1994): 709-712.

Žmitek K, Pogačnik T, Mervic L, Žmitek J, Pravst I. The effect of dietary intake of coenzyme Q10 on skin parameters and condition: Results of a randomised, placebo-controlled, double-blind study. Biofactors. 2017 Jan 2;43(1):132-140. doi: 10.1002/biof.1316. Epub 2016 Aug 22. PMID: 27548886.

Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017 Aug 12;9(8):866. doi: 10.3390/nu9080866. PMID: 28805671; PMCID: PMC5579659.

Gref R, Deloménie C, Maksimenko A, Gouadon E, Percoco G, Lati E, Desmaële D, Zouhiri F, Couvreur P. Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin. Sci Rep. 2020 Oct 9;10(1):16883. doi: 10.1038/s41598-020-72704-1. PMID: 33037252; PMCID: PMC7547010.

Schwartz JR, Marsh RG, Draelos ZD. Zinc and skin health: overview of physiology and pharmacology. Dermatol Surg. 2005 Jul;31(7 Pt 2):837-47; discussion 847. doi: 10.1111/j.1524-4725.2005.31729. PMID: 16029676.

Lipner SR. Rethinking biotin therapy for hair, nail, and skin disorders. J Am Acad Dermatol. 2018 Jun;78(6):1236-1238. doi: 10.1016/j.jaad.2018.02.018. Epub 2018 Feb 10. PMID: 29438761.

Patel DP, Swink SM, Castelo-Soccio L. A Review of the Use of Biotin for Hair Loss. Skin Appendage Disord. 2017 Aug;3(3):166-169. doi: 10.1159/000462981. Epub 2017 Apr 27. PMID: 28879195; PMCID: PMC5582478.

Piraccini BM, Berardesca E, Fabbrocini G, Micali G, Tosti A. Biotin: overview of the treatment of diseases of cutaneous appendages and of hyperseborrhea. G Ital Dermatol Venereol. 2019 Oct;154(5):557-566. doi: 10.23736/S0392-0488.19.06434-4. PMID: 31638351.

Kil MS, Kim CW, Kim SS. Analysis of serum zinc and copper concentrations in hair loss. Ann Dermatol. 2013 Nov;25(4):405-9. doi: 10.5021/ad.2013.25.4.405. Epub 2013 Nov 30. PMID: 24371385; PMCID: PMC3870206.

Marsh JM, Iveson R, Flagler MJ, Davis MG, Newland AB, Greis KD, Sun Y, Chaudhary T, Aistrup ER. Role of copper in photochemical damage to hair. Int J Cosmet Sci. 2014 Feb;36(1):32-8. doi: 10.1111/ics.12088. Epub 2013 Oct 10. PMID: 23962007.

Net content: 20 x 25ml

Warnings: do not exceed the recommended daily dose. Keep out of reach of children under 3 years of age. Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. A varied and balanced diet and a healthy lifestyle are important. Store in a cool, dry place. Avoid exposure to heat and sunlight.