YAMAMOTO RESEARCH
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 YAMAMOTO® RESEARCH
Yamamoto® Research Intenec® plus Yamamoto® Research Intenec® plus is a food supplement based on L-glutamine, extract for beef broth, extract for chicken broth, zinc, orange and grapefruit extracts and the probiotic microorganism Bacillus coagulans BC513, which favors the balance of intestinal flora*.
Gut health refers to the balance of microorganisms that live in the digestive tract. Taking care of gut health and maintaining the right balance of these microorganisms is vital for physical and mental health, immunity, and more. In fact, 60-80% of our immune system is in the intestine. Those who suffer from problems such as acid reflux, constipation, diarrhea, fermentation and abdominal cramps, bloating or nausea, understand how much the conditioning impact intestinal health can have in daily life. There are several factors and complex situations that can unbalance the balance of our intestine and favor these symptoms including diseases of viral or bacterial origin, parasites, toxins, psychophysical stress, dysbiosis, allergies and food intolerances, and more such as hormonal imbalances. Rapidly spreading, but still little recognized by many health professionals, "Leaky gut" is a relatively "modern" term to describe a condition in which bacteria, toxins, and badly digested foods enter through the "damaged", altered intestinal wall. more permeable. The immune system will then respond by attacking these "foreign objects", From a food point of view it is important to evaluate elements of the diet that are potentially inflammatory or irritating the mucosa, with as many that can promote better intestinal efficiency and health, but in addition to this, thanks to nutraceuticals, and in particular to some specific elements, we can have further important allies for the restoration of the intestinal barrier and intestinal flora, efficient and healthy. Intenec plus contains a series of these precious elements in favor of intestinal wall health, for which: L-Glutamine, Omnibroth ™ CBB and BBB, Microbiomex®, Bacillus Coagulans, Zinc. Glutamine is a semi-essential amino acid present mainly in skeletal muscle, intestine and liver, which performs numerous functions and is used in very large quantities by the cells of the immune system at the gastrointestinal level. In recent times, more and more emphasis is given to its role in "repairing" and improving the energy metabolism of the intestinal mucosa, as a precious substrate for the production of energy in cells and lymphocytes. Taking Glutamine has been shown to reduce bacterial permeability following intestinal damage. The bone broth was recommended as a powerful remedy for centuries in the traditional medicines of every people, from the Egyptian commitment to the Far East, for digestive problems, to soothe and heal the walls of the stomach and intestines but also to decongest the pathways. upper airways, and strengthen bones, skin, hair, nails, cartilage. Derived from beef or even from chicken, the bone edge is a real concentrated "superfood" of collagen, glycine, proline, glycosaminoglycans (GAG), glucosamine, hyaluronic acid, chondroitin sulfate, mineral salts, and with a definable amino acid profile business suit. A real soothing cure-all with "anti-aging" effects derived from the popular tradition that "works". Today it is also increasingly popular on the supplement market, MicrobiomeX® is a "flavobiotic" composed of two active flavonoids specially studied and clinically tested for the balance of the intestinal microbiome. Clinical studies have shown its anti-inflammatory effects given by the dual action of flavonoids and the positive change in the composition and well-being of the microbiome, improving the health of the intestine by strengthening the intestinal barrier and strengthening the immune system. Bacillus coagulans, is a sporogenic bacterium present in ours, capable of producing "spores" more clinically studied for the treatment of gastrointestinal disorders such as irritable bowel syndrome with predominant diarrhea (IBS), diverticulitis, vaginal infections, hypercholesterolemia, lactose intolerance, various types of malabsorption, or as an adjuvant to antibiotic therapy. The endospores produced by bacillus coagulans are formed by an internal core containing the momentarily inactivated genetic material and by a multilayered protective shell resistant to external attacks. They are metabolically "dormant" and resistant to radiation, and survive chemicals (pH stomach acid or bile) and heat (wet and dry). The presence of zinc as a very important mineral that intervenes in many body processes, including the contrast to the effect of free radicals and cellular aging, to stimulate the immune system, to facilitate the healing of wounds and ulcers, finds important utility also in promoting the regeneration of the epithelial tissue of the intestinal wall and the absorption of water and electrolytes, limiting the adhesion of pathogens to the cells of the intestinal epithelium, inhibiting the formation of bacterial biofilms. SCIENTIFIC REFERENCES Perna S, Alalwan TA, Alaali Z, Alnashaba T, Gasparri C, Infantino V, Hammad L, Riva A, Petrangolini G, Allegrini P, Rondanelli M. The Role of Glutamine in the Complex Interaction between Gut Microbiota and Health: A Narrative Review. Int J Mol Sci. 2019 Oct 22;20(20):5232. doi: 10.3390/ijms20205232. PMID: 31652531; PMCID: PMC6834172. Phillips MC, Olson LR. The immunologic role of the gastrointestinal tract. Crit Care Nurs Clin North Am. 1993 Mar;5(1):107-20. PMID: 8447988. Kim MH, Kim H. The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases. Int J Mol Sci. 2017 May 12;18(5):1051. doi: 10.3390/ijms18051051. PMID: 28498331; PMCID: PMC5454963. Chang WK, Yang KD, Shaio MF. Effect of glutamine on Th1 and Th2 cytokine responses of human peripheral blood mononuclear cells. Clin Immunol. 1999 Dec;93(3):294-301. doi: 10.1006/clim.1999.4788. PMID: 10600341. van der Hulst RR, van Kreel BK, von Meyenfeldt MF, Brummer RJ, Arends JW, Deutz NE, Soeters PB. Glutamine and the preservation of gut integrity. Lancet. 1993 May 29;341(8857):1363-5. doi: 10.1016 / 0140-6736 (93) 90939-e. PMID: 8098788. Vermeulen MA, de Jong J, Vaessen MJ, van Leeuwen PA, Houdijk AP. Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity. World J Gastroenterol. 2011 Mar 28;17(12):1569-73. doi: 10.3748/wjg.v17.i12.1569. PMID: 21472123; PMCID: PMC3070128. Zhu S, Huang M, Feng G, Miao Y, Wu H, Zeng M, Lo YM. Gelatin versus its two major degradation products, prolyl-hydroxyproline and glycine, as supportive therapy in experimental colitis in mice. Food Sci Nutr. 2018 Apr 16;6(4):1023-1031. doi: 10.1002/fsn3.639. PMID: 29983966; PMCID: PMC6021736. Scaldaferri F, Lopetuso LR, Petito V, Cufino V, Bilotta M, Arena V, Stigliano E, Maulucci G, Papi M, Emiliana CM, Poscia A, Franceschi F, Delogu G, Sanguinetti M, Spirito MD, Sgambato A, Gasbarrini A Tanned gelatin ameliorates acute colitis in mice by reinforcing mucus layer and modulating gut microbiota composition: Emerging role for 'gut barrier protectors' in IBD? United European Gastroenterol J. 2014 Apr; 2 (2): 113-22. doi: 10.1177 / 2050640614520867. PMID: 24918016; PMCID: PMC4040816. Lopetuso LR, Scaldaferri F, Bruno G, Petito V, Franceschi F, Gasbarrini A. The therapeutic management of gut barrier leaking: the emerging role for mucosal barrier protectors. Eur Rev Med Pharmacol Sci. 2015;19(6):1068-76. PMID: 25855934. Jäger R, Purpura M, Farmer S, Cash HA, Keller D. Probiotic Bacillus coagulans GBI-30, 6086 Improves Protein Absorption and Utilization. Probiotics Antimicrob Protein. 2018 Dec;10(4):611-615. doi: 10.1007/s12602-017-9354-y. PMID: 29196920; PMCID: PMC6208742. Mu Y, Cong Y. Bacillus coagulans and its applications in medicine. Benef Microbes. 2019 Jul 10;10(6):679-688. doi: 10.3920/BM2019.0016. Epub 2019 Jun 17. PMID: 31203635. Amoah K, Huang QC, Tan BP, Zhang S, Chi SY, Yang QH, Liu HY, Dong XH. Dietary supplementation of probiotic Bacillus coagulans ATCC 7050, improves the growth performance, intestinal morphology, microflora, immune response, and disease confrontation of Pacific white shrimp, Litopenaeus vannamei. Fish Shellfish Immunol. 2019 Apr;87:796-808. doi: 10.1016/j.fsi.2019.02.029. Epub 2019 Feb 18. PMID: 30790661. Majeed M, Nagabhushanam K, Arumugam S, Majeed S, Ali F. Bacillus coagulans MTCC 5856 for the management of major depression with irritable bowel syndrome: a randomised, double-blind, placebo controlled, multi-centre, pilot clinical study. Food Nutr Res. 2018 Jul 4;62. doi: 10.29219/fnr.v62.1218. PMID: 29997457; PMCID: PMC6034030. Maity C, Gupta AK, Saroj DB, Biyani A, Bagkar P, Kulkarni J, Dixit Y. Impact of a Gastrointestinal Stable Probiotic Supplement Bacillus coagulans LBSC on Human Gut Microbiome Modulation. J Diet Suppl. 2020 Sep 8:1-20. doi: 10.1080/19390211.2020.1814931. Epub ahead of print. PMID: 32896190. Muhamed PK, Vadstrup S. [Zinc is the most important trace element]. Ugeskr Laeger. 2014 Mar 3; 176 (5): V11120654. Danish. PMID: 25096007. Maret W, Sandstead HH. Zinc requirements and the risks and benefits of zinc supplementation. J Trace Elem Med Biol. 2006;20(1):3-18. doi: 10.1016/j.jtemb.2006.01.006. Epub 2006 Feb 21. PMID: 16632171. Fernández-Gallego N, Sánchez-Madrid F, Jiménez-Saiz R. Thinking small: Zinc sensing by the gut epithelium. Allergy. 2021 Jan;76(1):411-413. doi: 10.1111/all.14531. Epub 2020 Aug 17. PMID: 32738826. Chasapis CT, Ntoupa PA, Spiliopoulou CA, Stefanidou ME. Recent aspects of the effects of zinc on human health. Arch Toxicol. 2020 May;94(5):1443-1460. doi: 10.1007/s00204-020-02702-9. Epub 2020 May 12. PMID: 32394086. DIRECTIONS: dissolve 1 sachet in 200 ml of water and take once a day.
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| Nutrition information (Citrus Fruits) |
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| Per daily dose (1 sachet = 11 g) | |
| L-glutamine | 3000 mg |
| OmniBroth ™ CBB Chicken Broth Extract | 2500 mg |
| OmniBroth ™ BBB + Beef Broth Extract | 2500 mg |
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MicroBiomeX ®
of which orange
of which grapefruit
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500 mg
470 mg
30 mg
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Bacillus Coagulans BC513
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5x10⁹ (CFU**) |
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Zinc
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10 mg (100% RI) |
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Ingredients: L-glutamine, OmniBroth ™ BBB + (extract for powdered beef broth, emulsifying agent: sunflower lecithin), OmniBroth ™ CBB (extract for powdered chicken broth), acidity regulator: citric acid; flavorings, MicroBiomeX ® [orange powder (Citrus sinensis (L.) Osbeck, fruit with pericarp), grapefruit powder (Citrus paradisi Macfad., fruit with pericarp)], coloring: beta-carotene; anti-caking agent: silicon dioxide; sweeteners: sucralose, acesulfame K; zinc gluconate, Bacillus coagulans BC513 100 mld B/g.
* RI: Reference Intake
** CFU: colony forming units
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