YAMAMOTO RESEARCH
Semi di Pompelmo 20 sachets of 2 grams

Grapefruit seed extract is now considered a very powerful antiviral and bactericidal substance. The effectiveness of Grapefruit Seed Extract on bacteria, viruses, fungi and parasites has been demonstrated thanks to multiple and significant studies from laboratories and institutes from both Italy and all over the world, it is increasingly used in health care.

The active mechanism of Grapefruit Seed Extract seems to inhibit and weaken the structure and efficiency of the microbial cell membrane, which, by modifying itself, leads to the loss of cytoplasmic elements and becomes incapable of absorbing amino acids from the surrounding environment, which then kills the microorganisms due to a lack of nutritional intake.

We are all aware of the widespread and growing problem reported by various institutions regarding the consequences of the reckless use of antibiotics, which have led to an increase in drug-resistant bacteria, in addition to the unpleasant side effects of antibiotic use. The World Health Organization itself has launched continuous appeals to doctors and veterinarians, in an attempt to limit the use of antibiotics to cases where they are actually necessary. Grapefruit seed extract represents a valid and proven alternative treatment to multiple bacterial diseases bacterial which don't urgently need to be treated with antibiotics, guaranteeing a further quality, or selectivity, or the ability to distinguish between the pathogenic and good bacteria that constitute the "good" physiological bacterial flora. This in contrast to the negative action on physiological flora by synthetic antibiotics and antifungals, creating favourable conditions for recolonization by pathogenic bacteria. Grapefruit seed extract is therefore more than just an alternative, it is a genuine treatment for conditions were antibiotic treatment is not essential and which can have more favourable outcomes.

In this regard, as a demonstration of its unique and powerful efficacy, we know that grapefruit seed extract can be added to the detergents normally used for normal hygienic practices, such as shampoos, shower gels, bath gel, liquid hand soaps and for more intimate hygiene regimes, in the water of foot baths, in mouthwash, and in toothpastes to improve dental hygiene. It acts as a natural weapon against germs and can be used to disinfect environments and water, to eliminate mould even in showers, toilets and on all household surfaces, by diluting a few drops in water and applying it with a spray. In the same way it can be used as a disinfectant during cleaning. Now GSE is the most widely used disinfectant in clinics and hospitals in the United States.

The antibacterial action is demonstrated by many publications in scientific literature, following clinical studies both in vitro and in vivo where they show that Grapefruit Seed Extract proved to be active against over 800 strains of bacteria, demonstrating its broad spectrum of action (both Gram + and Gram-). It also seems to have an antiviral effect, but the results obtained on the efficacy of Grapefruit seed extract against viral strains although encouraging, require further in-depth studies and confirmation.

It also has excellent anti-fungal properties, combined with the ability to counteract numerous viruses and pathogenic bacteria, including the well-known and widespread Helicobacter pylori, which can lead to an excessive increase in acidity in the stomach, inflammation of the gastric mucosa, and gastric or duodenal ulcers.

The anti-fungal action can be useful to counteract the development of fungi, moulds and yeasts, including Candida albicans, usually present on the skin and mucous membranes without being harmful, but which can manifest virulence in the event of alteration of intestinal bacterial flora (notoriously beneficial), especially after prolonged use of antibiotics, or due to excessive stress, or a reduction in the immune system. In this respect, the clinical efficacy of the extract is shown to be effective against over 100 strains of yeasts and moulds including Candida albicans, responsible for recurrent mucosal infections and systemic affections. In particular, vaginal candida is very common in the western world and the relationship between it and systemic candidiasis has been proven beyond a doubt; the conventional approach involving the use of synthetic antifungals does not always bring satisfactory results both for the increasingly frequent resistance and for the devastating effect it has on "good" bacterial flora, which creates a "fertile" breeding ground for bad bacterial flora. The grapefruit seed extract is therefore a real recommended treatment in gynaecology for vaginal and systemic candidiasis.

The presence in grapefruit extract of many bioactive elements and vitamins such as A, C, E, and microelements such as selenium and zinc, also makes it an effective antioxidant against free radicals, which are responsible for cellular aging. Grapefruit seed extract also seems to be effective against Herpes simplex and influenza viruses, so much so that it seems to shorten the course of influenza and the common cold.

In support of continuous research and extension of its beneficial effects, this valuable nutraceutical has demonstrated other extraordinary properties as shown in recent studies by Polish researchers at the "Jagiellonian University Medical College" in Krakow. Scholars have demonstrated the ability of Grapefruit Extract to exert a protective action on the gastro-intestinal mucosa, whose conclusions were more than satisfactory to highlight cytoprotective activity through the increase in the synthesis of endogenous PG2 prostaglandins , the suppression of lipid peroxidation and the increase in intramucosal blood flow mediated by the release of nitric oxide by the sensory nerves. All this, combined with the increased activity of superoxide dismutase and the release of gastrin, reveals the repairing effect it can have on the gastrointestinal mucosa.

The wide potential of use of oral grapefruit seed extract (topical use further widens the field of action) is expressly referable to all these indications:

• CANDIDA (in all its forms: systemic, vaginal, oral) and other MYCOSES
• CYSTITIS
• PROSTATE CONDITIONS
• HAEMORROIDS
• INTESTINAL WORMS
• INTESTINAL DISORDERS AND FERMENTATIONS OF VARIOUS FLORA
• DIARREA (viral, bacterial, etc.)
• GASTRIC PROBLEMS (digestive difficulties, gastritis, ulcers, Helicobacter pylori infections, etc.)
• DISEASES OF THE RESPIRATORY SYSTEM (colds, sinusitis, otitis, tracheitis, bronchitis, etc.)

Grapefruit Seed Extract has no toxicity, either in the short or long term, at the doses normally recommended, and can therefore also be taken for a long period as a preventive measure even against relapses.

Beyond the beneficial properties of grapefruit seeds, it should be kept in mind that this fruit can interfere with some drugs, significantly affecting their biological activity through metabolic interactions. Grapefruit is able to significantly increase the bioavailability of different medicines, through a particular mechanism of inhibition of the activity of some enzymes that in the liver are responsible for the chemical transformation of the drugs. Following the action of these molecules, the drugs are "eliminated" less effectively and less quickly from the body, thus causing possible overdose effects due to the potential increase in plasma levels. For certain treatments, it is advisable to consult the prescribing doctor. The main drugs affected by potential interactions with grapefruit seeds are: statins, immunosuppressants, antihistamines, antiarrhythmics, calcium channel blockers, protease inhibitors, corticosteroids, and anxiolytics.

Net content: 20 x 2 g

Storage: keep in a cool dry place. Avoid exposure to heat and sunlight.

Warnings: do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a varied diet. A varied and balanced diet and a healthy lifestyle are important. Keep out of the reach of young children. Keep in a cool and dry place. Avoid exposure to heat sources and sunlight.