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YAMAMOTO RESEARCH
Vitamina K2 60 tablets

Rating 4,67/5 (Number of votes: 3) vote
Customer Reviews: 1

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€ 19,79 € 21,99

 


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Yamamoto Research Vitamina K2 60 tablets. Vitamin K2 is a food supplement that provides 200 µg of vitamin K per daily dose. Vitamin K ** contributes to the maintenance of normal bones.

See description


 
Yamamoto Research - Vitamina K2 - IAFSTORE.COM

YAMAMOTO® RESEARCH
Vitamin K2

Discovered in 1929, there are very recent acquisitions regarding the importance of vitamin K2 or "Menachione", a vitamin of bacterial origin and part of the vitamin K family, where the more "known" vitamin K1 or "Phylloquinone" belongs, of vegetable origin and involved in blood coagulation processes.

Vitamin K2 or Menaquinone, is a fat-soluble vitamin of bacterial origin and is found in dairy products and is produced by fermentation that occurs in the intestine, w recently through numerous studies, is increasingly demonstrating its great importance in terms of "prevention. "and health of the organism, in particular on the correct functionality and efficiency of the structure of the bone system and in the protection of the cardiovascular system, proving to be the protagonist of what in the medical-scientific field is defined as" the paradox of football ". In fact, with excessive calcification of the arterial walls, it opens up to very high risks of cardiovascular disease, stroke, and other degenerative pathologies, but at the same time,even a certain lack of calcium in the skeleton of the human body inexorably reduces the functionality of the bones.

At this point K2 comes into play, a real vitamin that we can define as "intelligent", in knowing how to direct calcium where it is needed, such as in the bones or teeth, and directs it, because it is potentially very dangerous, where it can physiologically be used. Vitamin K2 does not occur in high concentrations in the foods we commonly consume, and is found in fermented soybeans, goose liver, or some cheeses and even in milk or butter. There are various types of menaquinones in nature, and from this "family", the greatest bioactivity emerges from the MK-4 and MK-7 versions. However, research shows that it is the MK-7 form that is the most "bioavailable" on the oral route and with a longer duration of "active" presence within the body, compared to the MK-4 version.MK-7 is present only in particular fermented foods, see from cheeses to soy (the "Natto").

The daily dietary "minimum dose" should be around 25-50 mcg, but this adequate intake is still not easy to achieve with nutrition given the type of food so particular. Here, more and more, especially in the field of cardiovascular prevention and contrasting osteopenia or osteoporosis, its integration is suggested. In Japan, for example, we find this special vitamin through "Natto", a culinary preparation based on soy beans fermented with Bacilus subtilis (a bacterium found in the intestinal tract of animals and humans).

The extraordinary bioactivity of MK-7, sees a rapid diffusion of confirmations and fame in the scientific community, in preventing various diseases related to bone and cardiovascular health, is based on the fact that it allows calcium to be directed into the skeletal structure, avoiding its deposition in soft tissues such as arteries and brain, playing a key role in the activation of osteocalcin (OC), a fundamental protein in bone mineralization, capable of incorporating calcium in the bone matrix, helping to increase and improve synthesis of osteoblasts.

When our body has an adequate level of vitamin K2, it activates the Gla protein of the matrix (Matrix Gla-Protein or MGP) which is an inhibitor of vascular calcification and binds the calcium present in the vascular walls through a carboxylation process, transporting it to the bone tissue . Vitamin K2 binds to the calcium present and removes it from the deposit in the arteries and blood vessels, preventing the calcium circulating in the blood vessels from depositing in the arterial walls preventing their hardening together with the formation of cholesterol plaques, constitutes the major factor of risk for heart attack and stroke. This calcium is thus brought back to the bloodstream, to be conveyed "where it is needed", or as a reinforcement to the bone and dental structure, through the fixation of calcium.Action that occurs in synergy with vitamin D (of which it also promotes its absorption), and Magnesium (essential in contrasting osteopenia and osteoporosis). From this, studies show evident fundamental importance of how vitamin K2 significantly reduces bone loss even during the transition to menopause, a particularly critical period for women, where hormonal imbalance facilitates rapid loss of bone mass over time. .a particularly critical period for women, where hormonal imbalance facilitates rapid loss of bone mass over time.a particularly critical period for women, where hormonal imbalance facilitates rapid bone loss over time.

SCIENTIFIC REFERENCES:

Halder M, Petsophonsakul P, Akbulut AC, Pavlic A, Bohan F, Anderson E, Maresz K, Kramann R, Schurgers L. Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease. Int J Mol Sci. 2019 Feb 19; 20 (4): 896. doi: 10.3390 / ijms20040896. PMID: 30791399; PMCID: PMC6413124.

Myneni VD, Mezey E. Regulation of bone remodeling by vitamin K2. Oral Dis. 2017 Nov; 23 (8): 1021-1028. doi: 10.1111 / odi.12624. Epub 2017 Apr 5. PMID: 27976475; PMCID: PMC5471136.

Iwamoto J. Vitamin K₂ therapy for postmenopausal osteoporosis. Nutrients. 2014 May 16; 6 (5): 1971-80. doi: 10.3390 / nu6051971. PMID: 24841104; PMCID: PMC4042573.

Schurgers, LJ. Cranenburg, ECM and Vermeer, C. Matrix Gla – protein: The calcification inhibitor in need of vitamin K. Theme issue article. Thromb Haemost 2008; 100: 593-603.

Flore R, Ponziani FR, Di Rienzo TA, Zocco MA, Flex A, Gerardino L, Lupascu A, Santoro L, Santoliquido A, Di Stasio E, Chierici E, Lanti A, Tondi P, Gasbarrini A. Something more to say about calcium homeostasis: the role of vitamin K2 in vascular calcification and osteoporosis. Eur Rev Med Pharmacol Sci. 2013 Sep; 17 (18): 2433-40. PMID: 24089220.

Maresz K. Proper Calcium Use: Vitamin K2 as a Promoter of Bone and Cardiovascular Health. Integr Med (Encinitas). 2015 Feb; 14 (1): 34-9. PMID: 26770129; PMCID: PMC4566462.

Li W, Zhang S, Liu J, Liu Y, Liang Q. Vitamin K2 stimulates MC3T3 ‑ E1 osteoblast differentiation and mineralization through autophagy induction. Mol Med Rep. 2019 May; 19 (5): 3676-3684. doi: 10.3892 / mmr.2019.10040. Epub 2019 Mar 15. PMID: 30896842; PMCID: PMC6472126.

Jensen GS, Lenninger M, Ero MP, Benson KF. Consumption of nattokinase is associated with reduced blood pressure and von Willebrand factor, a cardiovascular risk marker: results from a randomized, double-blind, placebo-controlled, multicenter North American clinical trial. Integr Blood Press Control. 2016 Oct 13; 9: 95-104. doi: 10.2147 / IBPC.S99553. PMID: 27785095; PMCID: PMC5066864.

Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study. J Nutr. 2004; 134 (11): 3100-5.

Gast GCM, et al. A high menaquinone reduces the incidence of coronary heart disease in women, Nutr Metab Cardiovasc Dis. 2009; 19: 504-10.

Knapen MHJ, Braam LAJL, Drummen NE, Bekers O, Hoeks APG, Vermeer C. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women: double-blind randomized clinical trial. Thromb Haemost 2015 May: 19: 113 (5)

 

Directions: take 1 tablet a day with water.


Net content:12 g

. Storage conditions: keep tightly closed in a cool and dry place.


Warnings: do not exceed the recommended daily dose. The supplements are not intended as a substitute for a
varied diet . A varied and balanced diet and a healthy lifestyle are important. Keep out of the reach of
children under three years of age. Keep in a cold and dry place. Avoid exposure to heat sources and
sunlight. Do not disperse in the environment after use.


60 tablets  
Average analysis
Per daily dose (1 tablet)
  Per daily dose (1 tablet)
Vitamin K2 (MenaQ7®) 200 µg (267% AR *)
   
* AR = Reference Assumptions
Ingredients: MenaQ7® [menachione (vitamin K)], bulking agent: cellulose, anti-caking agents: magnesium salts of fatty acids, silicon dioxide.

Customer Reviews (1)

ottimo prodotto…
by USER ID 525458 on 05/08/2021
ottimo prodotto
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