ALPHAZER
Enerfuel® Liquid 500ml

Enerfuel® Liquid is a next-generation dietary supplement that takes the value of supplementation to a new level to support intense and sustained performance, in the form of a convenient, ready-to-use, fast-acting bottle.

Enerfuel® Liquid is the result of constant study and research by the Alphazer® R&D department, which has the invaluable support of many athletes who, through continuous monitoring and feedback, can directly create products that meet their key needs in their quest for ever-higher performance. This starts with managing blood sugar levels to achieve greater energy stability and clarity, further enhanced by the energy boost provided by caffeine. The combination of these components also promotes better oxygenation of the working muscles, rapid removal of lactic acid but without ceasing to support hydration, an extremely important factor in maintaining the most consistent performance possible.

Enerfuel® Liquid makes use of a range of top-quality nutrients and new-generation active elements unparalleled on the market, such as: Isomaltulose Palatinose®, Cyclodextrin Cluster Dextrin®, L-Citrulline, Beta-Alanine, Taurine, Freeze-dried Coconut Water, Caffeine, Watt'sUp®, Pycnogenol®, and Glycerol. Let's take a look at their characteristics in detail.

Cyclodextrins (Cluster Dextrin®) are now the most innovative form of carbohydrate to be taken before/during/after performance. This highly advanced form of carbohydrate, which has brought about a real revolution in sports supplementation, is made up of special glucose polymers, derived from the reaction between amylopectin and a specific enzyme. This allows the formation of glucose polymers with a very particular cyclic structure, with exceptional utilisation characteristics and an average molecular weight of 160,000 Daltons. In addition, these polymers have a very low osmolarity, which favours very rapid gastric emptying and equally rapid intestinal absorption. Energy is then released gradually, providing 'ready-to-use' energy. Post-workout, cyclodextrins are used to optimise muscle glycogen recovery and stimulate the absorption of amino acids by the muscle (so that protein synthesis is also indirectly improved).
Thanks to the characteristics listed above, Cyclodextrins are the most soluble and rapidly absorbable form of the new generation of carbohydrate, compared to any other source (such as maltodextrins and glucose/dextrose). They also have an additional advantage: long-lasting energy support, which will be sustained steadily over time, without incurring glycaemic spikes and 'crashes' and without raising insulin levels excessively. These problems, together with the limitations of gastrointestinal disorders, have in the past often limited the use of carbohydrates during training.

 

Isomaltulose (Palatinose™) is a carbohydrate, a disaccharide formed from glucose and fructose. It is naturally present, albeit in rather low concentrations, in honey and cane sugar syrup. It is produced using modern enzymatic conversion techniques from sucrose and, like sucrose, is fully digested in the intestine. A particular structural feature is that the bonds of the molecules forming isomaltulose (alpha(a)-1,6-glycosidic acid) are more stable than those of the molecules in sucrose. This is why this disaccharide is highly appreciated by sportsmen and women who want to maintain optimum performance: blood glucose and insulin levels rise much less than when other sugars are consumed. The special bond between its two components (fructose and glucose) slows down the rate of absorption. Subsequently, our intestinal disaccharidases, enzymes capable of breaking the bond between the two sugars, promote the absorption and bioavailability of the individual compounds. However, this process is much slower than for other, better-known sugars (such as sucrose). As a result, blood glucose and insulin levels will rise much less and without fluctuation, thus widening the time span of the blood glucose curve. This makes isomaltulose a slow-release energy source, capable of sustaining the body during prolonged and sustained training sessions, without incurring drops in performance due to hypoglycaemia or being affected and compromised by annoying gastrointestinal disorders (frequent with the use of other simple sugars). The effects of this disaccharide are confirmed both by scientific literature and directly by athletes in the field.

L-Citrulline is a non-essential amino acid, named after the fruit from which this substance was first isolated (watermelon, Latin for 'citrullus'). It performs important functions in the body, as a key intermediate in the urea cycle, where superfluous amino groups are removed. The urea cycle is a cycle of biochemical reactions that produces urea from ammonia, a substance that is 'toxic' to the body. Its accumulation also hinders the formation of muscle glycogen and promotes fatigue. The production of urea, enhanced by the introduction of Citrulline, is therefore essential for the elimination of these waste substances, which can affect the performance of athletes. Citrulline is also known to stimulate vasodilation, as it is converted into L-arginine, resulting in massive production of nitric oxide (NO). NO is a powerful molecule which dilates blood vessels to allow muscles to receive more oxygen and nutrients, while at the same time removing metabolic waste products. Citrulline is also known for its antioxidant effects, and from recent experimental studies, also for its anabolic and anti-catabolic activities.

Beta-Alanine is a non-essential amino acid, well known in the sporting world for its efficacy and credibility, backed up by excellent confirmation in numerous scientific studies. Once taken, β-alanine is combined with L-histidine to synthesise Carnosine, a dipeptide which is the real player in the 'buffer' effect on lactate. Beta Alanine supplementation has been shown to raise levels of this molecule in muscles by 80%, where it will act as a neutralising agent against hydrogen ions. In practical terms, it will reduce the build-up of unpleasant lactic acid in the muscles, while also significantly reducing muscle fatigue. Beta-Alanine is also an excellent antioxidant, useful against the formation of free radicals produced by exercise. Supplementation with this amino acid leads to increases in strength performance, and is recommended not only for training aimed at body building or power sports, but also in sports with sprints or changes in intensity (such as cycling, athletics, crossfit or triathlon). Supplementation for these types of sport leads to increased performance, proving to be a powerful support in curbing fatigue and disposing of lactic acid. Beta-Alanine supplementation has also been shown to help prevent muscle decline (sarcopenia) in older people.

 

Taurine is a conditionally essential amino acid, known in sports supplementation as it helps reduce oxidative damage induced by intense exercise. It promotes better peripheral oxygenation, as well as combating the build-up of lactic acid, helping to maintain more efficient muscle contractility, even during intense exercise. Its action intervenes in neurotransmission, membrane stabilisation and neurological development, delaying the onset of central fatigue and muscle fatigue. Taurine also plays a key role in the synthesis of bile acids, and is important for vision and eye health.

Coconut water has proved to be an excellent ally for sportsmen and women for hydrogen-saline replenishment and for its excellent thirst-quenching properties, containing a high concentration of highly bioavailable minerals. It contains a high concentration of highly bioavailable minerals. In particular, it contains high quantities of potassium (600 mg per litre, twice as much as a banana), as well as magnesium, sodium, calcium, phosphorus, manganese, zinc and iron. It is a very valuable food, fat-free, cholesterol-free and with very little sugar.

Caffeine is the most historically used natural ergogenic substance in sport, helping to increase resistance to fatigue and improve performance by increasing tolerance to fatigue and pain thresholds and also improving concentration. It is a psychostimulant substance capable of improving performance by promoting the use of fats as fuel, saving glucose reserves. It affects so many biological reactions and, although its effects on the body are numerous, most of them are due to its stimulant effects. A caffeine intake level of up to 400mg per day poses no safety problems in adults, but rather has a positive effect on the performance of most athletes.

Watt'sUp® is a bioflavonoid derived from the sweet orange in hesperidin. It is used for its properties in all types of sporting activity, from strength sports to endurance sports, due to its ability to make the action of the mitochondria, our cellular 'powerhouse', more efficient. By generating more ATP at constant oxygen levels, this translates into greater energy, aerobic endurance and anaerobic power. It also improves tissue oxygenation and has antioxidant and antiphlogistic effects.

Pycnogenol® is a patented mixture of antioxidant substances extracted mainly from French maritime pine bark. It is one of the most powerful antioxidant complexes in nature, as well as having a number of properties beneficial to various other aspects of health. In the field of sports performance, it is used not only as a powerful antioxidant against free radicals produced by exercise, but also to improve resistance to fatigue, bringing a marked improvement in vascular microcirculation, capillary resistance and peripheral tissue oxygenation.

 

Glycerol, or glycerine, is a chemical compound consisting of two primary alcohol groups and a secondary alcohol group, and is known in sports as a hyperhydrating agent with osmotic properties. It is used to prevent and alleviate states of dehydration with negative consequences on performance (but also on the athlete's overall health). It is particularly popular with cyclists, marathon runners or athletes facing long-distance races and/or adverse weather conditions, where it is easy to become dehydrated. Glycerol acts on several fronts and once taken orally, it moves rapidly through the body fluids before being metabolised, and increases the osmotic pressure and total volume of water in the body through the process of 'osmosis'. This happens because water is able to diffuse through body membranes in response to changes in osmotic pressure. These changes are often caused by an imbalance between molecules on either side of the membrane in question (in humans most commonly salt and water), and the body is well-calibrated in maintaining intracellular osmotic pressure. In fact, cells adjust their volume to account for external pressure shifts. In raising the osmotic pressure within the body fluids, glycerol over a period of time draws in and retains a greater influx of water throughout the body (until it is physiologically metabolised), as if it were a 'pump', effectively increasing its overall volume. In this way, the body not only retains more water resulting in 'hyperhydration', but will also use fluids more efficiently for thermoregulation, promoting hydration of the muscles during physical exertion.

 

Benefits of our supplement

 

Why choose Enerfuel LIQUID?
- Ideal for supporting sustained performance;
- No risk of glycaemic dips or spikes;
- Antioxidant action;
- Improves cognitive ability and concentration during training;
- Ensures energy supply for your sports activities;
- Hydrating effect and support for hydrosaline balance;
- Perfect for supporting and maximising physical exertion;
- Complete and effective mix of differently-released carbohydrates;
- Practical, ready-to-use bottle that you can carry with you at all times.

 

When and how to take it

We recommend taking 50 ml a day, either pure or diluted in a glass of water. Depending on individual goals, it can be taken pre-workout (about 30 minutes before) or during performance to maximise performance.

 

SCIENTIFIC REFERENCES

Takii H, Ishihara K, Kometani T, Okada S, Fushiki T. Enhancement of swimming endurance in mice by highly branched cyclic dextrin. Biosci Biotechnol Biochem 1999;63:2045-52

Takii H, Takii NY, Kometani T, Nishimura T, Nakae T, Kuriki T, et al. Fluids containing a highly branched cyclic dextrin influence the gastric emptying rate. Int J Sports Med 2005;26:314-9

Furuyashiki T, Tanimoto H, Yokoyama Y, Kitaura Y, Kuriki T, Shimomura Y. Effects of ingesting highly branched cyclic dextrin during endurance exercise on rating of perceived exertion and blood components associated with energy metabolism. Biosci Biotechnol Biochem. 2014;78(12):2117-9. doi: 10.1080/09168451.2014.943654. Epub 2014 Jul 31. PMID: 25080121.

Suzuki K, Shiraishi K, Yoshitani K, Sugama K, Kometani T. Effect of a sports drink based on highly-branched cyclic dextrin on cytokine responses to exhaustive endurance exercise. J Sports Med Phys Fitness. 2014 Oct;54(5):622-30. PMID: 25270782.

Effects of ingesting highly branched cyclic dextrin during endurance exercise on rating of perceived exertion and blood components associated with energy metabolism. Furuyashiki T, Tanimoto H, Yokoyama Y, Kitaura Y, Kuriki T, Shimomura Y. Biosci Biotechnol Biochem. 2014;78(12):2117-9

Kometani T, Takii H, Shiraki T, Nomura T. Endurance enhancing effect of cyclic Cluster Dextrin® . FOOD Style21. 2003;7:62–65.

Takii H, Kometani T, Nishimura T, Kuriki T, Fushiki T. A sports drink based on highly branched cyclic dextrin generates few gastrointestinal disorders in untrained men during bicycle exercise. Food Sci. Technol. Res. 2004;10:428–431.10.3136/fstr.10.428

Effect of a sports drink based on hoghly-branched cyclic dextrin on cytokine responses to exhaustive endurance exercise. Suzuki K, et al. J Sports Med Phys Fitness 2014

König D, Zdzieblik D, Holz A, Theis S, Gollhofer A. Substrate Utilization and Cycling Performance Following Palatinose™ Ingestion: A Randomized, Double-Blind, Controlled Trial. Nutrients. 2016 Jun 23;8(7):390. doi: 10.3390/nu8070390. PMID: 27347996; PMCID: PMC4963866.

Young H, Benton D. The effect of using isomaltulose (Palatinose™) to modulate the glycaemic properties of breakfast on the cognitive performance of children. Eur J Nutr. 2015 Sep;54(6):1013-20. doi: 10.1007/s00394-014-0779-8. Epub 2014 Oct 14. PMID: 25311061; PMCID: PMC4540784.

Stevenson EJ, Watson A, Theis S, Holz A, Harper LD, Russell M. A comparison of isomaltulose versus maltodextrin ingestion during soccer-specific exercise. Eur J Appl Physiol. 2017 Nov;117(11):2321-2333. doi: 10.1007/s00421-017-3719-5. Epub 2017 Sep 19. Erratum in: Eur J Appl Physiol. 2017 Nov 16;: PMID: 28929343; PMCID: PMC5700989.

Maresch CC, Petry SF, Theis S, Bosy-Westphal A, Linn T. Low Glycemic Index Prototype Isomaltulose-Update of Clinical Trials. Nutrients. 2017 Apr 13;9(4):381. doi: 10.3390/nu9040381. PMID: 28406437; PMCID: PMC5409720.

Miyashita M, Hamada Y, Fujihira K, Namura S, Sakazaki M, Miyasaka K, Nagai Y. The effects of isomaltulose ingestion on gastric parameters and cycling performance in young men. J Exerc Sci Fit. 2019 Jul;17(3):101-107. doi: 10.1016/j.jesf.2019.06.001. Epub 2019 Jun 13. PMID: 31303872; PMCID: PMC6599884.

Amano T, Sugiyama Y, Okumura J, Fujii N, Kenny GP, Nishiyasu T, Inoue Y, Kondo N, Sasagawa K, Enoki Y, Maejima D. Effects of isomaltulose ingestion on postexercise hydration state and heat loss responses in young men. Exp Physiol. 2019 Oct;104(10):1494-1504. doi: 10.1113/EP087843. Epub 2019 Aug 26. PMID: 31400765.

de Groot E, Schweitzer L, Theis S. Efficacy of Isomaltulose Compared to Sucrose in Modulating Endothelial Function in Overweight Adults. Nutrients. 2020 Jan 3;12(1):141. doi: 10.3390/nu12010141. PMID: 31947853; PMCID: PMC7019610.

Kawaguchi T, Nakano D, Oriishi T, Torimura T. Effects of isomaltulose on insulin resistance and metabolites in patients with non‑alcoholic fatty liver disease: A metabolomic analysis. Mol Med Rep. 2018 Aug;18(2):2033-2042. doi: 10.3892/mmr.2018.9223. Epub 2018 Jun 26. PMID: 29956790; PMCID: PMC6072173.

Gonzalez AM, Trexler ET. Effects of Citrulline Supplementation on Exercise Performance in Humans: A Review of the Current Literature. J Strength Cond Res. 2020 May;34(5):1480-1495. doi: 10.1519/JSC.0000000000003426. PMID: 31977835.

Suzuki T, Morita M, Kobayashi Y, Kamimura A. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study. J Int Soc Sports Nutr. 2016;13(1):6.

Glenn JM, Gray M, Jensen A, Stone MS, Vincenzo JL. Acute citrulline-malate supplementation improves maximal strength and anaerobic power in female, masters athletes tennis players. Eur J Sport Sci. 2016 Nov;16(8):1095-103. doi: 10.1080/17461391.2016.1158321. Epub 2016 Mar 28. PMID: 27017895.

Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res. 2010 May;24(5):1215-22. doi: 10.1519/JSC.0b013e3181cb28e0. PMID: 20386132.

Saunders B et al. β-alanine supplementation to improve exercise capacity and performance: a systematic review and meta-analysis. Br J Sports Med. 2017 Apr;51(8):658-669.

Hobson RM et al. Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino Acids. 2012 Jul;43(1):25-37.

Dankel SJ et al. Do metabolites that are produced during resistance exercise enhance muscle hypertrophy? Eur J Appl Physiol. 2017 Nov;117(11):2125-2135.

Burke LM. Caffeine and sports performance. Appl Physiol Nutr Metab. 2008 Dec;33(6):1319-34. doi: 10.1139/H08-130. PMID: 19088794.

Graham TE. Caffeine and exercise: metabolism, endurance and performance. Sports Med. 2001;31(11):785-807. doi: 10.2165/00007256-200131110-00002. PMID: 11583104.

Southward K, Rutherfurd-Markwick KJ, Ali A. The Effect of Acute Caffeine Ingestion on Endurance Performance: A Systematic Review and Meta-Analysis. Sports Med. 2018 Aug;48(8):1913-1928. doi: 10.1007/s40279-018-0939-8. Erratum in: Sports Med. 2018 Aug 9;: PMID: 29876876.

Pycnogenol® is more effective in preventing of the post-thrombotic syndrome and a new venous thrombosis than Aspirin, sulodexide and ticlopidine.Belcaro G, Dugall M, Hu S, Feragalli B, Cotellese R, Ledda A, Corsi M, Ricci A, Ippolito E, Errichi BM, Cornelli U, Cesarone MR, Hosoi M

Prevention of recurrent venous thrombosis and post-thrombotic syndrome. Minerva Cardioangiol 66(3): 238-245, 2018

CLINICAL STUDY: Pycnogenol® seems to decrease passive dilatation and stretching and gives vein walls a greater tonic recovery and elasticity that allows the vein to recover its original shape after dynamic stresses. Belcaro G, Dugall M, Luzzi R, Hosoi M, Corsi M
Improvement of Venous Tone with Pycnogenol® in Chronic Venous Insufficiency: An Ex Vivo Study on Venous Segments. Int J Angiol 23:47-52, 2014

Pycnogenol® helps to maintain a healthy circulation through vasodilatation, anti platelet aggregation, free radical scavenging and capillary sealing effects. The role of endothelial nitric oxide (NO) is also discussed. Rohdewald P
Reducing the risk for stroke and heart infarction with Pycnogenol®.Eur Bull Drug Res 7: 14-18, 1999

Pycnogenol® counteracts the constriction of blood vessels. The vaso-relaxant activity of Pycnogenol® is mediated through nitric oxide.
Fitzpatrick DF, Bing B, Rohdewald P
Endothelium-dependent vascular effects of Pycnogenol®.J Cardiovasc Pharmacol 32: 509-515, 1998

CLINICAL STUDY: Pycnogenol® reduces oxidative stress and improves physical performance in athletes.

Vinciguerra G, Belcaro G, Bonanni E, Cesarone MR, Ledda A, Hosoi M, Dugall M, Cacchio M, Cornelli U
Evaluation of the effects of supplementation with Pycnogenol® on fitness in normal subjects with the Army Physical Fitness Test and in performances of athletes in the 100-minute triathlon.
J sports Med Phys Fitness 53(6): 644-654, 2013

CLINICAL STUDY: Pycnogenol® consumption increases vasodilatation by 42% in young healthy men, which warrants sufficient blood and oxygen supply to performing muscle.
Nishioka K, Hidaka T, Nakamura S, Umemura T, Jitsuiki D, Soga J, Goto C, Chayama K, Yoshizumi M, Higashi Y Pycnogenol®, French Maritime Pine Bark Extract, augments endothelium-dependent vasodilation in humans. Hypertens Res 30: 775-780, 2007

CLINICAL STUDY: Pycnogenol® reduces muscular pain and cramps in athletes and in patients with vascular problems or poor blood circulation of the legs.
Vinciguerra G, Belcaro G, Cesarone MR, Rohdewald P, Stuard S, Ricci A, Di Renzo A, Hosoi M, Dugall M, Ledda A, Cacchio M, Acerbi G, Fano F

Cramps and muscular pain: prevention with Pycnogenol® in normal subjects, venous patients, athletes, claudicants and in diabetic microangiopathy.
Angiology 57: 331-339, 2006

Nelson JL, Robergs RA. Exploring the potential ergogenic effects of glycerol hyperhydration. Sports Med 2007;37:981-1000.

Van Rosendal SP, Coombes JS. Glycerol use in hyperhydration and rehydration: Scientific update. Med Sport Sci 2012;59:104-12.

Montner P, Stark DM, Riedesel ML, Murata G, Robergs R, Timms M, Chick TW. Pre-exercise glycerol hydration improves cycling endurance time. Int J Sports Med 1996;17:27-33.

Latzka WA, Sawka MN, Montain SJ, Skrinar GS, Fielding RA, Matott RP, Pandolf KB. Hyperhydration: tolerance and cardiovascular effects during uncompensable exercise-heat stress. J Appl Physiol 1998;84:1858-64.

Coutts A, Reaburn P, Mummery K, Holmes M. The effect of glycerol hyperhydration on Olympic distance triathlon performance in high ambient temperatures. Int J Sport Nutr Exerc Metab 2002;12:105-19

Hitchins S, Martin DT, Burke LM, et al. Glycerol hyperhydration improves cycle time trial performance in hot humid conditions. Eur J Appl Physiol 1999;80:494-501.

Anderson MJ, Cotter JD, Garnham AP, Casley DJ, Febbraio MA. Effect of glycerol-induced hyperhydration on thermoregulation and metabolism during exercise in the heat. Int J Sport Nutr Exerc Metab 2001;11:315-33.

Goulet EB, De La Flore A, Savoie FA, Gosselin J. Salt + Glycerol-Induced Hyperhydration Enhances Fluid Retention More than Salt- or Glycerol-Induced Hyperhydration. Int J Sport Nutr Exerc Metab 2017; https://doi.org/10.1123/ijsnem.2017-0310

Modalità d’uso:50 ml per day to be taken pure or diluted in a glass of water.

Net content: 500ml

Warnings: do not exceed the recommended daily dose. Food supplements are not intended as a substitute for a varied diet. A varied and balanced diet and a healthy lifestyle are important. Keep out of the reach of children under three years of age. Do not exceed the total daily dose of 400 mg of caffeine from all sources. Do not take the product before going to bed or in the hours immediately preceding sleep and in conjunction with alcohol. Keep in a cold and dry place. Avoid exposure to heat sources and sunlight.