YAMAMOTO RESEARCH
Resveratrolo ResVida™ 60 capsules

Resveratrol is considered an "anti-aging" nutraceutical par excellence, capable of modulating a large number of physiological processes in the organism related to aging, whose effects seem to be able to mimic the effects of caloric restriction by activating the "sirtuins" , and triggering a series of processes that protect the cell from environmental stresses. Resveratrol protects vessels from plaque formation and stimulates the production of nitric oxide responsible for vasodilation processes and inhibits platelet activation and aggregation, as well as improving control over blood sugar and insulin sensitivity.

Resveratrol reduces oxidative and inflammatory processes, modulating the expression of a large number of genes and enzymes such as telomerase, in favoring the repair of damaged DNA and generally improving the metabolic structure of the cell making it potentially "younger". 

The ResVida ™ brand is the most bioavailable version of reseveratrol on the market, boasting the highest standard of quality control and purity from contaminants.

Resveratrol is a substance that has attracted a lot of interest among researchers dealing with all those diseases and disorders related to aging, becoming one of the most interesting natural compounds in the "anti-aging" field.

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a plant substance that is part of the group of stilbenes belonging to the polyphenol family, the most abundant source of which is red grapes, particularly in its skins. Obviously present in wine and red grape sauce and in fair quantities, they are also found in berries and in the polygonum cuspidatum plant. 

Resveratrol was discovered in 1992 following the phenomenon called "French Paradox", as although in France the consumption of foods rich in saturated fats is very high, mortality from cardiovascular diseases was much lower than in other countries with eating habits similar (like the United States). Based on this paradox it was thought that the potential "protective factor" was red wine. Per this reason, we began to investigate the beneficial properties of wine and thus resveratrol was discovered, as the protagonist of these potential protective effects for the body. Unfortunately, however, the quantity of wine necessary to reach an effective concentration of resveratrol such as to be able to exert its effects, is well above the daily dose of wine " 

The world of nutraceuticals could not fail to consider the potential of resveratrol, considered an "elixir of youth" since its discovery. Scientific research has revealed how it is capable of activating the longevity gene in some yeast strains, extending life expectancy by 70%. Its action works as if one entered a calorie restriction regime, activating the SIRT1 gene, and would seem to increase the activity of telomerase, an enzyme that protects our chromosomes and whose activity decreases during cellular aging. Researches relating to various animal species but which also have potential for humans and which deserve a specific study.

So "a good glass of wine is really so good for your health"? Research shows that resveratrol has a real protective action on the cardiovascular system through various mechanisms of action. These include the inhibition of the oxidation of low-density lipoproteins (LDL, the Protein that carry "bad cholesterol") and the reduction of the formation of atherosclerotic plaques. Several studies have shown that taking resveratrol also has antihypertensive effects due to its antioxidant activity and stimulation of endothelial nitric oxide (NO) production, inhibition of vascular inflammation and prevention of platelet aggregation.

The "antiaging" effect is also well known on the skin, where there are a series of specific receptors for polyphenols and to which resveratrol binds and performs a series of actions, from reducing skin oxidative stress, which is particularly "welcome" the increase in the production of collagen or MMP-1, and in acting on the fibroblasts of the dermis and reducing the photo-aging process of the skin. 

In fact, just like other polyphenols, resveratrol is a very powerful antioxidant that reduces oxidative stress and does so by increasing the production of antioxidant molecules, as well as being capable of anti-inflammatory properties. In fact, by activating sirt1 it is able to inhibit the formation in our body of a series of inflammatory factors including NF-kB, a transcription factor that increases the production of cytokines by the cells of the immune system. pro-inflammatory (such as TNF-alpha, IL-1beta, IL-6) and cyclooxygenase (COX-1 and 2) that is the enzyme that transforms arachidonic acid into inflammatory prostaglandins and thromboxanes.

Research has also shown that resveratrol improves glucose homeostasis, decreases insulin resistance, protects pancreatic beta cells, improves insulin secretion and improves metabolic disturbances. The effects induced by resveratrol are closely related to its ability to increase the expression / activity of AMPK and SIRT1 in various tissues of people with diabetes. 

It is the commercial use of resveratrol that has presented problems related to its poor solubility and its rapid metabolism that make it very little bioavailable. To overcome this limitation and not limit the effects of this "anti-aging" nutraceutical, we wanted to insert the resVida® brand, (produced by DSM Nutritional Products), which is the best product on the market based on 99 resveratrol. % in pure form of trans-resveratrol. Resvida not only guarantees maximum bioavailability, but also the maximum purity of the product, free from pesticides and herbicides, with the maximum guarantee of safety in terms of quality controls.

SCIENTIFIC REFERENCES

Timmers S, Auwerx J, Schrauwen P. The journey of resveratrol from yeast to human. Aging (Albany NY). 2012 Mar;4(3):146-58. doi: 10.18632/aging.100445. PMID: 22436213; PMCID: PMC3348475.

Castaldo L, Narváez A, Izzo L, Graziani G, Gaspari A, Minno GD, Ritieni A. Red Wine Consumption and Cardiovascular Health. Molecules. 2019 Oct 8; 24 (19): 3626. doi: 10.3390 / molecules24193626. PMID: 31597344; PMCID: PMC6804046.

Catalgol B, Batirel S, Taga Y, Ozer NK. Resveratrol: French paradox revisited. Front Pharmacol. 2012 Jul 17;3:141. doi: 10.3389/fphar.2012.00141. PMID: 22822401; PMCID: PMC3398412.

Weiskirchen S, Weiskirchen R. Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy? Adv Nutr. 2016 Jul 15;7(4):706-18. doi: 10.3945/an.115.011627. PMID: 27422505; PMCID: PMC4942868.

Bonnefont-Rousselot D. Resveratrol and Cardiovascular Diseases. Nutrients. 2016 May 2;8(5):250. doi: 10.3390/nu8050250. PMID: 27144581; PMCID: PMC4882663.

Oncotarget. 2017 Aug 9. A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction. Li J, Zhang CX, Liu YM, Chen KL, Chen G.

Xia N, Daiber A, Förstermann U, Li H. Antioxidant effects of resveratrol in the cardiovascular system. Br J Pharmacol. 2017 Jun;174(12):1633-1646. doi: 10.1111/bph.13492. Epub 2016 May 6. PMID: 27058985; PMCID: PMC5446570.

Bird JK, Raederstorff D, Weber P, Steinert RE. Cardiovascular and Antiobesity Effects of Resveratrol Mediated through the Gut Microbiota. Adv Nutr. 2017 Nov 15;8(6):839-849. doi: 10.3945/an.117.016568. PMID: 29141969; PMCID: PMC5682996

Timmers S, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MKC, Kunz I, Schrauwen-Hinderling VB, Blaak E, Auwerx J, Schrauwen P. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011 Nov 2; 14 (5): 612-22. doi: 10.1016 / j.cmet.2011.10.002. PMID: 22055504; PMCID: PMC3880862.

Villalba JM, Alcaín FJ. Sirtuin activators and inhibitors. Biofactors. 2012 Sep-Oct;38(5):349-59. doi: 10.1002/biof.1032. Epub 2012 Jun 25. PMID: 22730114; PMCID: PMC3467333.

Baker NA, English V, Sunkara M, Morris AJ, Pearson KJ, Cassis LA. Resveratrol protects against polychlorinated biphenyl-mediated impairment of glucose homeostasis in adipocytes. J Nutr Biochem. 2013 Dec;24(12):2168-74. doi: 10.1016/j.jnutbio.2013.08.009. PMID: 24231106; PMCID: PMC4066417.

Department of Animal Physiology and Biochemistry, Poznan University of Life Sciences, Polonia. Szkudelski T, Szkudelska K. Resveratrol and diabetes: From animal to human studies. Biochim Biophys Acta 2015, Jun;1852(6):1145-54.

Edwards JA, Beck M, Riegger C, Bausch J. Safety of resveratrol with examples for high purity, trans-resveratrol, resVida(®). Ann N Y Acad Sci. 2011 Jan;1215:131-7. doi: 10.1111/j.1749-6632.2010.05855.x. PMID: 21261651.

Net content: 13.8 g

Storage conditions: keep tightly closed in a cool and dry place.

Warnings: do not exceed the recommended daily dose. The supplements are not intended as a substitute for a varied diet. A varied and balanced diet and a healthy lifestyle are important. Keep out of the reach of children
under three years of age. In case of concomitant drug intake, contact your doctor. Keep in a cold and dry place. Avoid exposure to heat sources and sunlight. Do not disperse in the environment after use.