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Home › Sports nutrition › SAMe
Dimezim Stick 20 stick - YAMAMOTO RESEARCH

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YAMAMOTO RESEARCH
Dimezim Stick 20 stick

Rating 5/5 (Number of votes: 5)

Yamamoto® Research Dimezim Stick 20 sticks. Dimezim Stick is a food supplement providing 200mg of SAM-e and 400mg of betaine per daily dose.

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Yamamoto Research - Sam-E - IAFSTORE.COM

YAMAMOTO® RESEARCH
Yamamoto® Research SAM-e

SAM-e is a food supplement that provides 200 mg of SAM-e and 400 mg of betaine per daily dose.

S-Adenosylmethionine ("SAM-e") is an important compound produced by our organism, from the combination of the amino acid Methionine with adenosyl triphosphate (ATP), discovered in Italy in 1952, it is an extraordinarily interesting molecule and well studied in the literature in its different peculiarities and potentials. S-Adenosylmentionine is found in practically every cell of the human body, where it performs various fundamental biological functions, but is particularly concentrated in the brain and liver, where it is involved in over 40 biochemical reactions of our organism, such as in "methylation" reactions. , of critical importance for brain chemistry and detoxification reactions. It is one of the main donors of methyl in the synthesis of hormones, nucleic acids, Protein and phospholipids. SAM-e has become well known and used as a molecule necessary for the synthesis of neurotransmitters related to mood, such as norepinephrine, dopamine and serotonin, and plays a fundamental role in intracellular metabolic exchanges, and promotes physiological levels of acetylcholine, which helps to maintain cognitive functions and to counteract the neurodegeneration that occurs with or aging processes. It is also necessary in the synthesis of various components containing sulfur, such as the powerful antioxidant glutathione and of various components of the cartilage where it exerts an interesting beneficial action. Commonly used in the medical field a long time ago.

SAM-e has long been recognized in the clinical field also for its beneficial action on the liver, therefore not only an enhancing agent on mood, but also an interesting hepatoprotective molecule capable of counteracting liver damage caused by various toxic agents, such as alcohol, drugs, or pollutants.

Thanks to this new formulation with the comfortable and practical stick pack, it is possible to quickly have the beneficial effects of SAM-e at any time of the day and to guarantee better absorption capacity.

SCIENTIFIC REFERENCES:

Mato JM, Alvarez Chiva V. Utilidad clínica de la S-adenosilmetionina [Clinical use of S-adenosylmethionine]. Rev Clin Esp. 1983 Jan 31;168(2):149-50. Spanish. PMID: 6856905.

Chavez M. SAMe: S-Adenosylmethionine. Am J Health Syst Pharm. 2000 Jan 15;57(2):119-23. doi: 10.1093/ajhp/57.2.119. PMID: 10688238.

Stramentinoli G. Pharmacologic aspects of S-adenosylmethionine. Pharmacokinetics and pharmacodynamics. Am J Med. 1987 Nov 20;83(5A):35-42. doi: 10.1016/0002-9343(87)90849-7. PMID: 3318439.

Caruso I, Fumagalli M, Boccassini L, Sarzi Puttini P, Ciniselli G, Cavallari G. Antidepressant activity of S-adenosylmethionine. Lancet. 1984 Apr 21;1(8382):904. doi: 10.1016/s0140-6736(84)91360-6. PMID: 6143204.

Wilson A. S-Adenosyl Methionine (SAMe) for Depression in Adults. Issues Ment Health Nurs. 2019 Aug;40(8):725-726. doi: 10.1080/01612840.2017.1392161. Epub 2019 Jan 11. PMID: 30633610.

Sharma A, Gerbarg P, Bottiglieri T, Massoumi L, Carpenter LL, Lavretsky H, Muskin PR, Brown RP, Mischoulon D; as Work Group of the American Psychiatric Association Council on Research. S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research. J Clin Psychiatry. 2017 Jun;78(6):e656-e667. doi: 10.4088/JCP.16r11113. PMID: 28682528; PMCID: PMC5501081.

Jori E, Dallari A. La S-adenosilmetionina (SAM) in terapia geriatrica [S-adenosylmethionine (SAM) in geriatric therapy]. Minerva Med. 1973 Sep 26;64(67):3485-91. Italian. PMID: 4746873.

Grégoire S, Millecamps M, Naso L, Do Carmo S, Cuello AC, Szyf M, Stone LS. Therapeutic benefits of the methyl donor S-adenosylmethionine on nerve injury-induced mechanical hypersensitivity and cognitive impairment in mice. Pain. 2017 May;158(5):802-810. doi: 10.1097/j.pain.0000000000000811. PMID: 28030474.
Rutjes AW, Nüesch E, Reichenbach S, Jüni P. S-Adenosylmethionine for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2009 Oct 7;2009(4):CD007321. doi: 10.1002/14651858.CD007321.pub2. PMID: 19821403; PMCID: PMC7061276.

Labò G, Gasbarrini GB. Attività terapeutiche della solfo-adenosilmetionina in alcune epatopatie croniche [Therapeutic action of S-adenosylmethionine in some chronic hepatopathies]. Minerva Med. 1975 May 2;66(33):1563-70. Italian. PMID: 1143692.

Galizia I, Oldani L, Macritchie K, Amari E, Dougall D, Jones TN, Lam RW, Massei GJ, Yatham LN, Young AH. S-adenosyl methionine (SAMe) for depression in adults. Cochrane Database Syst Rev. 2016 Oct 10;10(10):CD011286. doi: 10.1002/14651858.CD011286.pub2. PMID: 27727432; PMCID: PMC6457972.

Mato JM, Martínez-Chantar ML, Lu SC. S-adenosylmethionine metabolism and liver disease. Ann Hepatol. 2013 Mar-Apr;12(2):183-9. PMID: 23396728; PMCID: PMC4027041.

Avila MA, García-Trevijano ER, Martínez-Chantar ML, Latasa MU, Pérez-Mato I, Martínez-Cruz LA, del Pino MM, Corrales FJ, Mato JM. S-Adenosylmethionine revisited: its essential role in the regulation of liver function. Alcohol. 2002 Jul;27(3):163-7. doi: 10.1016/s0741-8329(02)00228-8. PMID: 12163144.

King AL, Mantena SK, Andringa KK, Millender-Swain T, Dunham-Snary KJ, Oliva CR, Griguer CE, Bailey SM. The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease. Redox Biol. 2016 Oct;9:188-197. doi: 10.1016/j.redox.2016.08.005. Epub 2016 Aug 17. PMID: 27566282; PMCID: PMC5007436.

DIRECTIONS: take 2 orosoluble sticks a day.


Net content: 26 g


Warnings: do not exceed the recommended daily dose. Food supplements are not intended as a substitute for a varied diet. A varied and balanced diet and a healthy lifestyle are important. Keep out of the reach of children under three years of age. Keep in a cold and dry place. Avoid exposure to heat sources and sunlight.

20 sticks
 Red Fruits
Nutrition information  
  Per daily dose (2 sticks)
   
SAM-e
 200 mg
Betaina
 400 mg
   
Ingredients: maltodextrin, S-adenosyl-L-methionine disulfate P-toluenesulfonate (SAM-e), betaine, bulking agent: sorbitol; anti-caking agent: silicon dioxide; flavoring, sweetener: sucralose.

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