YAMAMOTO RESEARCH
Vitamina B6 Piridossina 10mg 60 tablets

Vitamin B6, also known as pyridoxine, is a water-soluble vitamin belonging to the B vitamin complex, which must be taken with food, as our body is unable to produce it. Vitamin B6, even if it does not degrade with heat, is sensitive to light and oxidation processes.

It is abundantly present in beef, lamb, pork, duck, turkey and other fatty poultry. It is also present in fish such as salmon or seafood, eggs, milk and its derivatives. In the plant world it is present, to a lesser extent, in rice, whole grains, wheat, oats, wholemeal bread and pasta, but also in spinach, peas, lentils, beans, potatoes, in soy, chickpeas, plums, and avocado.

Its main function is linked to the synthesis of neurotransmitters, see norepinephrine, serotonin, myelin, which protect the brain, but is involved in many chemical and metabolic processes of our body (as for the other B vitamins), where it intervenes as a coenzyme of various enzymatic systems involved as in particular in the metabolism of amino acids, in the reactions of transamination, decarboxylation and racenaization. It is necessary for the conversion of tryptophan into niacin and together with other B vitamins, vitamin B6 participates in the metabolism of homocysteine and regulates its plasma levels. At the metabolic level, its role as a coenzyme also intervenes in muscle and hepatic glycogen phosphorylase, involved in the process of splitting glycogen into glucose units.Vitamin B6 also participates in the formation of red blood cells, in the control of the nervous and hormonal systems (particularly important in the female body) and in the protection of the immune system.

An overt deficiency of vitamin B6 is not very common, but it can emerge with the intake of estrogen, steroids, in pregnant or breastfeeding women, during the menstrual cycle, or for those who consume alcohol and can increase the risk associated with the increase. cardiovascular disease or cause repercussions on peripheral nerves, skin, mucous membranes and blood cells. The central nervous system is also affected in children. Cases in which targeted supplementation is useful.

Vitamin B6 is important in the following confirmed cases for: hereditary sideroblastic anemia, neuritis and for the protection of the nervous system and brain functions, in preventing serious degenerative diseases of the central nervous system, in protecting vision on macular degeneration and in decreasing levels of homocysteine carrying out a cardioprotective action. According to some studies, vitamin B6 helps relieve some of the typical symptoms of PMS, including nausea, fatigue and headache. A further benefit of vitamin B6 concerns the protection of the health of the hair and also of the skin, strengthening the hair and making it more voluminous, in preventing scalp disorders, such as dandruff and overproduction of sebum.

Furthermore, according to recent studies it is also useful for relieving alopecia, because it inhibits the production of the enzyme 5-alpha-reductase which is responsible for the transformation of testosterone into DHT, or dehydrotestosterone, a compound that is deposited in the hair follicle, obstructing it. , and causing difficulties in hair growth, which will also have a much shorter life cycle.

SCIENTIFIC REFERENCES:

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Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy--A Review. Nutrients. 2016 Jan 27;8(2):68. doi: 10.3390/nu8020068. PMID: 26828517; PMCID: PMC4772032.

Brown MJ, Ameer MA, Beier K. Vitamin B6 Deficiency. 2020 Oct 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan–. PMID: 29261855.

Dakshinamurti S, Dakshinamurti K. Antihypertensive and neuroprotective actions of pyridoxine and its derivatives. Can J Physiol Pharmacol. 2015 Dec;93(12):1083-90. doi: 10.1139/cjpp-2015-0098. Epub 2015 May 11. PMID: 26281007.

Jung HY, Kim DW, Nam SM, Kim JW, Chung JY, Won MH, Seong JK, Yoon YS, Yoo DY, Hwang IK. Pyridoxine improves hippocampal cognitive function via increases of serotonin turnover and tyrosine hydroxylase, and its association with CB1 cannabinoid receptor-interacting protein and the CB1 cannabinoid receptor pathway. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3142-3153. doi: 10.1016/j.bbagen.2017.09.006. Epub 2017 Sep 19. PMID: 28935605.

HAVARD CW. Pyridoxine-responsive anaemia. Br Med J. 1961 Dec 30;2(5269):1756-7. doi: 10.1136/bmj.2.5269.1756. PMID: 13905463; PMCID: PMC1970944.

Morris AA, Kožich V, Santra S, Andria G, Ben-Omran TI, Chakrapani AB, Crushell E, Henderson MJ, Hochuli M, Huemer M, Janssen MC, Maillot F, Mayne PD, McNulty J, Morrison TM, Ogier H, O'Sullivan S, Pavlíková M, de Almeida IT, Terry A, Yap S, Blom HJ, Chapman KA. Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency. J Inherit Metab Dis. 2017 Jan;40(1):49-74. doi: 10.1007/s10545-016-9979-0. Epub 2016 Oct 24. PMID: 27778219; PMCID: PMC5203861.

Ueland PM, Ulvik A, Rios-Avila L, Midttun Ø, Gregory JF. Direct and Functional Biomarkers of Vitamin B6 Status. Annu Rev Nutr. 2015;35:33-70. doi: 10.1146/annurev-nutr-071714-034330. Epub 2015 May 13. PMID: 25974692; PMCID: PMC5988249.

Head KA. Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev. 2006 Dec;11(4):294-329. PMID: 17176168.

Ravat S, Shah M. Role of pyridoxine in the management of infantile spasms. Neurol India. 2018 Mar-Apr;66(2):330-331. doi: 10.4103/0028-3886.227278. PMID: 29547149.

Kjeldby IK, Fosnes GS, Ligaarden SC, Farup PG. Vitamin B6 deficiency and diseases in elderly people--a study in nursing homes. BMC Geriatr. 2013 Feb 8;13:13. doi: 10.1186/1471-2318-13-13. PMID: 23394203; PMCID: PMC3579689.

Coburn SP, Slominski A, Mahuren JD, Wortsman J, Hessle L, Millan JL. Cutaneous metabolism of vitamin B-6. J Invest Dermatol. 2003 Feb;120(2):292-300. doi: 10.1046/j.1523-1747.2003.12034.x. PMID: 12542535.

Albersen M, Bosma M, Jans JJ, Hofstede FC, van Hasselt PM, de Sain-van der Velden MG, Visser G, Verhoeven-Duif NM. Vitamin B6 in plasma and cerebrospinal fluid of children. PLoS One. 2015 Mar 11;10(3):e0120972. doi: 10.1371/journal.pone.0120972. PMID: 25760040; PMCID: PMC4356616.

Tanaka Y, Aso T, Ono J, Hosoi R, Kaneko T. Androgenetic Alopecia Treatment in Asian Men. J Clin Aesthet Dermatol. 2018 Jul;11(7):32-35. Epub 2018 Jul 1. PMID: 30057663; PMCID: PMC6057731.

Net content: 9 g

Warnings: do not exceed the recommended daily dose. The supplements are not intended as a substitute for a varied diet. A varied and balanced diet and a healthy lifestyle are important. Keep out of the reach of children under three years of age. Keep in a cold and dry place. Avoid exposure to heat sources and sunlight.