YAMAMOTO RESEARCH
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 YAMAMOTO® RESEARCH
Epadex® Epadex is the new Yamamoto® Research product that makes use of the synergy of some precious natural elements that act in support of normal liver function and from a purifying point of view, helping it in its various essential activities at the level of our body, based on: artichoke, Desmodio, turmeric and sillimarin with very high absorption.
Once a very rare vegetable, today the artichoke is widely cultivated in regions with a temperate winter climate. Already known in the sixteenth century, it is one of the most suitable plants to promote the liver, digestive and purifying functions of the body. Silymarin is the best known natural substance to support liver function and purification of the organism, and it is also one of the most studied plant extracts with known mechanisms of action. Silymarin is commonly used for liver health and normal functioning. To enhance the efficacy of the action of Sillimarin, in Epadex there is a version that uses the form of the Phytosome, (complexed with lecithin) "Sillimarina Fitosoma®", as a transport vehicle, which guarantees a clear reduction in bioavailability. (The focus is on extracts from milk thistle fruits (Silybum marianum (L.) which mainly contain silymarin, an isomeric compound of silibinin, isosilybinin, silicristin and silidianin.) Among the most potentially active natural substances to promote physiological liver function, Desmodium Adscendens has recently emerged, an African perennial and climbing plant, native to many tropical areas of South America, Africa and Asia, this plant is widely used in Peru, Brazil , Bolivia, Cameroon, Ghana, Guinea. It was thanks to the interest of a French doctor, Dr. P. Tubéry that he entered the common Western practice, who discovered his talents in 1965 when he was in Cameroon practicing in a religious hospital. Once back in France, with the collaboration of a pharmacist colleague, Tubéry began to study the biochemical mechanisms in depth. Subsequently, thanks to research, this herbal element was approved in France and in many other Western countries. Turmeric remains one of those natural substances whose multifaceted value boasts of numerous studies. This spice with a particular characteristic aroma that has been part of Ayurvedic medicine for millennia, is associated with the support capacity, to promote physiological liver function. Given the known strong difficulties of turmeric in being completely bioavailable and therefore being able to boast of its properties, Epadex contains the Curcugreen ™ BCM-95® version, a particular 100% patent blended with turmeric extract that makes use of a dossier of over 68 clinical studies and 15-year quality-safety control monitoring. The number "95" that characterizes the "Curcugreen ™ BCM-95®" patent concerns the degree of standardization to 95% of the curcuminoid-essential oils complex, which allows a unique absorption and synergy of action that has shown an extraordinary bioavailability from 7 to 9 times higher than that of the most common turmeric extracts at 95% standardization. The turmeric used is GMO-free, and does not contain any excipient or artificial coloring, it is gluten-free and does not contain yeasts, starches, dairy products and soy. SCIENTIFIC LITERATURE:
“Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits” Plant Foods Hum Nutr (2015) 70:441–453 DOI 10.1007/s11130-015-0503-8Panahi Y et al. Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. Phytother Res. 2018 Jul. Improvement bioavailability of silymarin ameliorates severe dyslipidemia associated with metabolic syndrome.Poruba M, Kazdová L, Oliyarnyk O, Malinská H, Matusková Z, Tozzi di Angelo I, Skop V, Vecera R.Xenobiotica. 2015;45(9):751-6. doi: 10.3109/00498254.2015.1010633. Silymarin liposomes improves oral bioavailability of silybin besides targeting hepatocytes, and immune cells. Kumar N, Rai A, Reddy ND, Raj PV, Jain P, Deshpande P, Mathew G, Kutty NG, Udupa N, Rao CM.Pharmacol Rep. 2014 Oct;66(5):788-98. doi: 10.1016/j.pharep.2014.04.007. A phase I and pharmacokinetic study of silybin-phytosome in prostate cancer patients. Flaig TW, Gustafson DL, Su LJ, Zirrolli JA, Crighton F, Harrison GS, Pierson AS, Agarwal R, Glodé LM.Invest New Drugs. 2007 Apr;25(2):139-46. A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). Kidd P, Head K.Altern Med Rev. 2005 Sep;10(3):193-203. Review. Gupta SC, Kismali G, Aggarwal BB. Curcumin, a component of turmeric: from farm to pharmacy. Biofactors. 2013;39(1):2-13. Goel A, Kunnumakkara AB, Aggarwal BB. Curcumin as “Curecumin”: from kitchen to clinic. Biochem Pharmacol. 2008;75(4):787-809. Seriki SA. Analysis of Phytoconstituents of Desmodium Adscendens in Relation to its Therapeutic Properties. Am J Biomed Sci & Res. 2019 - 2(4). AJBSR.MS.ID.000598. DOI: 10.34297/AJBSR.2019.02.000598 Received: February 08, 2019 | Published: April 23, 2019 Safety of Desmodium adscendens extract on hepatocytes and renal cells. Protective effect against oxidative stress J Intercult Ethnopharmacol. 2015 Jan-Mar; 4(1): 1–5. Published online 2014 Nov 28. doi: 10.5455/jice.20141013041312 Céline François,1 Mourad Fares,1 Claudio Baiocchi,2 and Jean Michel Maixent3 http://www.oroverde.cz/stranka/manayupa-medicinal-plants/ https://www.crp-phyto.com/img/cms/Desmodium%20def%20Ethnopharm%2053.pdf https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566765/ https://www.crp-phyto.com/img/cms/Desmodium%20def%20Ethnopharm%2053.pdf https://www.crp-phyto.com/img/cms/Desmodium%20def%20Ethnopharm%2053.pdf https://www.crp-phyto.com/img/cms/Desmodium%20def%20Ethnopharm%2053.pdf https://www.crp-phyto.com/img/cms/Desmodium%20def%20Ethnopharm%2053.pdf Epstein J, Sanderson IR, Macdonald TT. Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies. Br J Nutr. 2010;103(11):1545-1557. Basnet P, Skalko-Basnet N. Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules. 2011;16(6):4567-4598. Goel A, Jhurani S, Aggarwal BB. Multi-targeted therapy by curcumin: how spicy is it? Mol Nutr Food Res. 2008;52(9):1010-1030. Anand P, Thomas SG, Kunnumakkara AB, et al. Biological activities of curcumin and its analogues (congeners) made by man and Mother Nature. Biochem Phar- macol. 2008;76(11):1590-1611. Sanmukhani J, Satodia V, Trivedi J et al. Efficacy and safety of curcumin in major depressive disorder: A randomized controlled trial. Phytother Res 2014 Apr;28(4):579-85 . Lopresti AL, Maes M, Maker GL, Hood SD, Drummond PD. Curcumin for the treatment of major depression: a randomised, double-blind, placebo controlled study. J Affect Disord. 2014;167:368-375. Meng B, Li J, Cao H. Antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complications. Curr Pharm Des. 2013;19(11):2101- 2113. Ali T, Shakir F, Morton J. Curcumin and inflammatory bowel disease: biological mechanisms and clinical implication. Digestion. 2012;85(4):249-255. Baliga MS, Joseph N, Venkataranganna MV, Saxena A, Ponemone V, Fayad R. Curcumin, an active component of turmeric in the prevention and treat- ment of ulcerative colitis: preclinical and clinical observations. Food Funct. 2012;3(11):1109-1117. Monroy A, Lithgow GJ, Alavez S. Curcumin and neurodegenerative diseases. Biofactors. 2013;39(1):122-132. Nutrients. 2018 Jul; 10(7): 855. Published online 2018 Jul 1. doi: 10.3390/nu10070855Curcumin in Liver Diseases: A Systematic Review of the Cellular Mechanisms of Oxidative Stress and Clinical Perspective Mohammad Hosein Farzaei,1,* Mahdi Zobeiri,2 Fatemeh Parvizi,1 Fardous F. El-Senduny,3 Ilias Marmouzi,4Ericsson Coy-Barrera,5 Rozita Naseri,2 Seyed Mohammad Nabavi,6 Roja Rahimi,7 and Mohammad Abdollahi8,* Curcumin and Liver Disease: from Chemistry to Medicine Published in Comprehensive Reviews in Food Science and Food Safety in 2014 Nabavi, Seyed Fazel; Daglia, Maria; Moghaddam, Akbar Hajizadeh; Habtemariam, Solomon; Nabavi, Seyed Mohammad Pharmacological actions of curcumin in liver diseases or damage Yadira Rivera-Espinoza1, Pablo Muriel Liver Int. 2009 Nov;29(10):1457-66. doi: 10.1111/j.1478-3231.2009.02086.x. Directions: ake 2 tablets a day with water.
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| 30 tablets |
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| Daily dose: 2 tablets | |
| Servings per container: 15 | |
| Nutrition information | Per daily dose (2 tablets) |
| Artichoke extract of which caffeoylquinic acid |
300 mg 15 mg |
| Desmodium extract | 200 mg |
| Milk thistle extract of which silybin |
66 mg 35 mg |
| Total curcuminoids from turmeric (Curcugreen™) | 66,3 mg |
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Ingredients: bulking agents: cellulose, dicalcium phosphate; artichoke dry extract (Cynara scolymus L.) leaves 5% caffeoylquinic acid, milk thistle dry extract [milk thistle (Silybum marianum (L.) Gaertn.) fruit 17,5% silybin, glazing agent: soy lecithin], desmodium dry extract (Desmodium adscendens (SW.) DC.) leaves, total curcuminoids from turmeric Curcugreen™ (Curcuma longa L.) rhizome, anti-caking agents: silicon dioxide, magnesium salts of fatty acids.
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