YAMAMOTO RESEARCH
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 YAMAMOTO® RESEARCH
Yamamoto® Research Vitamin D3 + Calcium Vitamin D3 + Calcium is a food supplement that provides 25 μg of vitamin D3 and 250 mg of calcium per daily dose. Vitamin D3 contributes to the maintenance of normal bones and to normal blood calcium levels. Calcium is needed for the maintenance of normal bones.
If we think of the most abundant and important mineral for the purpose of mass, the regenerative "dynamism" and the solidity of the bone tissue of the human body, that is Calcium. It is present in practically all types of cells in the body and intervenes in many of its biochemical reactions, allows muscle contraction, contraction of the heart muscle, blood vessels to regulate blood pressure, communication between nerve cells, also contributing to digestion. and blood clotting. Research has revealed its correlation to the degeneration of the bone structure with aging, and it is no coincidence that calcium intake is often insufficient in older people who assimilate calcium less efficiently in the intestine, while d ' on the other hand, their need increases and favors the onset of a frequent bone pathology, osteoporosis. Osteoporosis is a potential factor of very high risk for greater bone fragility that opens up to vertebral problems, falls and fractures, a complex problem, related to multiple causes, from genetic, to environmental, nutritional and above all hormonal ones both on women but also concerning man during after the threshold of forty and fifty years. This is fueled by low food income,and the calcium must, by force majeure, be drawn from the "warehouse" of the bone reserves in the structure of the body's own skeleton, thus making them more fragile and prone to fractures. Preventing osteoporosis and counteracting osteopenia of the bone tissue is one of the major topics researched in the scientific field related to hormones and pre- and menopause for women, where the first hormonal imbalances begin to silently alter the turnover of bone tissue . In these cases, it is commonly suggested its dietary supplementation through specific supplements, to prevent or limit osteoporosis and ensure your bones the need for these insufficient nutrients with the diet, which should preferably be associated with vitamin D3 (cholecalciferol) to allow theassimilation of calcium by the bone in a more effective way, and allowing it to maintain its structure more resistant, flexible and strong, This turnover is based on a continuous re-change of the components of this particular tissue, regulated by biochemical balances in which Calcium and Vitamin D play a fundamental role in the dynamic turnover of the bone constitution. Specifically, Calcium represents an essential element for the formation of bones and teeth, and for the modulation of their maintenance of turnover, where with phosphorus it constitutes "hydroxyapatite", the inorganic component of bone tissue, where it will play a fundamental structural role , together with carrying out numerous other vital organic functions such as from blood coagulation to various enzymatic activities,from cell multiplication and differentiation to the regulation of neuromuscular activity. Vitamin D is also involved in these processes, which favors both normal levels of calcium in the blood and the physiological absorption and use of calcium and phosphorus, supporting the maintenance of normal bones and teeth. Its integration is absolutely beneficial and synergistic as in recent years, a lack of Vitamin D often emerges which could be due to poor physiological production by the skin, as a potential consequence of a decrease in exposure to the sun by the population. In particular, the synergistic presence of (increasingly appreciated by the scientific community) Vitamin D stimulates the absorption of calcium and phosphorus in the intestine, regulates blood levels of calcium and promotes its deposition in the bone tissue, also participating in the physiological " calcium turnover "in the blood. SCIENTIFIC REFERENCES Peacock M. Calcium metabolism in health and disease. Clin J Am Soc Nephrol. 2010 Jan; 5 Suppl 1: S23-30. doi: 10.2215 / CJN.05910809. PMID: 20089499. Reid IR, Bristow SM, Bolland MJ. Calcium supplements: benefits and risks. J Intern Med. 2015 Oct; 278 (4): 354-68. doi: 10.1111 / joim.12394. Epub 2015 Jul 14. Erratum in: J Intern Med. 2016 Mar; 279 (3): 311. PMID: 26174589. Fischer V, Haffner-Luntzer M, Amling M, Ignatius A. Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover. Eur Cell Mater. 2018 Jun 22; 35: 365-385. doi: 10.22203 / eCM.v035a25. PMID: 29931664. Khammissa RAG, Fourie J, Motswaledi MH, Ballyram R, Lemmer J, Feller L. The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health. Biomed Res Int. 2018 May 22; 2018: 9276380. doi: 10.1155 / 2018/9276380. PMID: 29951549; PMCID: PMC5987305. Kopic S, Geibel JP. Gastric acid, calcium absorption, and their impact on bone health. Physiol Rev. 2013 Jan; 93 (1): 189-268. doi: 10.1152 / physrev.00015.2012. PMID: 23303909. Murray TM. Prevention and management of osteoporosis: consensus statements from the Scientific Advisory Board of the Osteoporosis Society of Canada. 4. Calcium nutrition and osteoporosis. CMAJ. 1996 Oct 1; 155 (7): 935-9. PMID: 8837543; PMCID: PMC1335457. Weaver CM, Alexander DD, Boushey CJ, Dawson-Hughes B, Lappe JM, LeBoff MS, Liu S, Looker AC, Wallace TC, Wang DD. Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int. 2016 Jan; 27 (1): 367-76. doi: 10.1007 / s00198-015-3386-5. Epub 2015 Oct 28. Erratum in: Osteoporos Int. 2016 Aug; 27 (8): 2643-6. PMID: 26510847; PMCID: PMC4715837. Uenishi K, Tokiwa M, Kato S, Shiraki M. Stimulation of intestinal calcium absorption by orally administrated vitamin D3 compounds: a prospective open-label randomized trial in osteoporosis. Osteoporos Int. 2018 Mar; 29 (3): 723-732. doi: 10.1007 / s00198-017-4351-2. Epub 2017 Dec 23. Erratum in: Osteoporos Int. 2018 Feb 26 ;: PMID: 29273827; PMCID: PMC5834567. Park KS, Yoo JI, Kim HY, Jang S, Park Y, Ha YC. Education and exercise program improves osteoporosis knowledge and changes calcium and vitamin D dietary intake in community dwelling elderly. BMC Public Health. 2017 Dec 19; 17 (1): 966. doi: 10.1186 / s12889-017-4966-4. PMID: 29258608; PMCID: PMC5737912. Marshall K, Teo L, Shanahan C, Legette L, Mitmesser SH. Inadequate calcium and vitamin D intake and osteoporosis risk in older Americans living in poverty with food insecurities. PLoS One. 2020 Jul 8; 15 (7): e0235042. doi: 10.1371 / journal.pone.0235042. PMID: 32639966; PMCID: PMC7343143. Harvey NC, Biver E, Kaufman JM, Bauer J, Branco J, Brandi ML, Bruyère O, Coxam V, Cruz-Jentoft A, Czerwinski E, Dimai H, Fardellone P, Landi F, Reginster JY, Dawson-Hughes B, Kanis JA, Rizzoli R, Cooper C. The role of calcium supplementation in healthy musculoskeletal aging: An expert consensus meeting of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the International Foundation for Osteoporosis (IOF) . Osteoporos Int. 2017 Feb; 28 (2): 447-462. doi: 10.1007 / s00198-016-3773-6. Epub 2016 Oct 20. PMID: 27761590; PMCID: PMC5274536. Direction: take 1 softgel a day with water.
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| 60 softgels |
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| Nutrition information | ||
| Daily dose: 1 softgel | ||
| Servings per container: 60 | ||
| Per daily dose (1 softgel) | % AR * | |
| Vitamin D3 | 25 µg | 500 |
| Calcium | 250 mg | 31 |
| * AR: reference assumptions | ||
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Ingredients: sunflower oil, food gelatin (capsule), resistance agent: glycerol, dye: iron oxides and hydroxides, calcium carbonate, emulsifier: sunflower lecithin, thickener: mono- and diglycerides of fatty acids, vitamin D3 (cholecalciferol ).
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